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Primary Information | |
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| BoMiProt ID | Bomi7252 |
| Protein Name | Multidrug resistance-associated protein 1/ATP-binding cassette sub-family C member 1/Glutathione-S-conjugate-translocating ATPase ABCC1/Leukotriene C(4)transporter/LTC4 transporter |
| Organism | Bos taurus |
| Uniprot ID | Q8HXQ5 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776648.1 |
| Aminoacid Length | 1530 |
| Molecular Weight | 171666 |
| FASTA Sequence | Download |
| Gene Name | ABCC1 |
| Gene ID | 281588 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | It reduces the oxidative stress generated by smoking, a risk factor for Chronic Obstructive Pulmonary Disease (COPD). |
| Biochemical Properties | ABCC1 is an ABC transporter with a wide substrate spectrum that includes several different drugs and has a broadly accepted role in tumor multidrug resistance. |
| PTMs | Glycosylation at Asn and Phosphorylation at Ser,SUMOylation,Hydroxylation at C-3 of Lys-22 by JMJD7,Ubl conjugation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|Q8HXQ5|MRP1_BOVIN Multidrug resistance-associated protein 1 OS=Bos taurus OX=9913 GN=ABCC1 PE=1 SV=1 MALRDFCSVDGSDLFWEWN*19VTWNTSNPDFTKCFQNTVLVWVPCSYLWVCFPFYFLYLSHH DRGYIQMTHLNKAKTALGFLLWIVCWADLFYSFWERSMGKLLAPVFLVSPTLLGITMLLA TFLIQIERRRGVQSSGIMLTFWLIALLCALAILRSKIMTALKEDARVDVFRDVTFYIYFS LVLIQLVLSCFSDRSPLFSETINDPNPCPESSASFLSRITFWWITGMMVQGYRQPLESTD LWSLNKEDTSEQVVPVLVKNWKKECAKSRKQPVKIVY*277SSKDPAKPKGSS*289KVDVNEEAEAL IVKCPQKERDPSLFKVLYKTFGPYFLMSFLFKAVHDLMMFAGPEILKLLINFVNDKKAPE WQGYFYTALLFISACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNAARKSSTV GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPLN AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK KSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRFPLNILP MVISSIVQASVSLKRLRVFLSHEDLDPDSIQRRPIKDAGATNSITVKNATFTWARNDPPT LHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVTVKGSVAYVPQQAWIQNI SLRENILFGRQLQERYYKAVVEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR AVYCDSDVYLLDDPLSAVDAHVGKHIFENVIGPKGLLKNKTRLLVTHAISYLPQMDVIIV MSGGKISEMGSYQELLARDGAFAEFLRTYASAEQEQGQPEDGLAGVGGPGKEVKQMENGM LVTDTAGKQMQRQLS*915SSSSYSRDVSQHHTS*930TAELRKPGPTEETWKLVEADKAQTGQVKLS VYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDPIVN*1005GTQEHTQVRLSVYGA LGISQGITVFGYSMAVSIGGIFASRRLHLDLLHNVLRSPISFFERTPSGNLVNRFSKELD TVDSMIPQVIKMFMGSLFNVIGACIIILLATPMAAVIIPPLGLIYFFVQRFYVASSRQLK RLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAV RLECVGNCIVLFASLFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAV ERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYGLRYREDLDLVLKHINVTIDGGE KVGIVGRTGAGKSSLTLGLFRIKESAEGEIIIDDINIAKIGLHDLRFKITIIPQDPVLFS GSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLA RALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLD KGEIQEWGSPSDLLQQRGLFYSMAKDSGLV |
| CATH | Matched CATH superfamily n/a |
| Predicted Disorder Regions | NA |
| DisProt Annotation | |
| TM Helix Prediction | 14TMHs; (36-58), (76-94), (103-125), (132-154), (173-191), (324-346), (365-387), (437-459), (463-485), (544-566), (585-607), (968-990), (1021-1043), (1095-1117) |
| Significance of PTMs | SUMOylation by UBE2I in response to MEKK1-mediated stimuli.Polyubiquitinated induces proteolytic degradation and is impaired by interaction with ZC3H15. |
| PDB ID | 5UJ9,5UJA,6BHU,6UY0, |
| Additional Comments | Overexpression of the transporter proteins, such as P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP), confers resistance to the treatment of acute myeloid leukemia (AML). |
| Bibliography | 1.Budulac SE, Postma DS, Hiemstra PS, Lapperre TS, Kunz LI, Vonk JM, Marike Boezen H, Timens W; Glucold Study Group. Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD. Eur J Pharmacol. 2012 Dec 5;696(1-3):136-42. doi: 10.1016/j.ejphar.2012.08.015. Epub 2012 Sep 12. PMID: 22982023. 2.da Silveira Júnior LS, Soares VL, Jardim da Silva AS, Gil EA, Pereira de Araújo MDG, Merces Gonçalves CA, Paiva AS, Moura de Oliveira TM, Oliveira GHM, Kramer Cavacanti E Silva DG, de Araújo Moura Lemos TM, Moretti Rebecchi IM, de Farias Sales VS, Luchessi AD, Cavalcanti Júnior GB. P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications. Int J Lab Hematol. 2020 Oct;42(5):594-603. doi: 10.1111/ijlh.13241. Epub 2020 May 26. PMID: 32452631. 3.Cole SP. Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter. J Biol Chem. 2014;289:30880–30888. |