|Muellerian-inhibiting factor/Anti-Muellerian hormone/Muellerian-inhibiting substance
|Ref Sequence ID
|Protein Existence Status
|AMH is highly correlated with a woman's age and number of primordial ovarian follicles, and has been shown to predict time to menopause in women in their 40s. For these reasons, it was assumed that AMH levels could predict a woman's reproductive potential or serve as a 'fertility test'.
|Anti-Mullerian hormone (AMH) is a dimeric gly- € coprotein member of the transforming growth factorbeta-b family secreted by the granulosa cells of early antral follicles
|Significance in milk
|Anti-Müllerian hormone (AMH) is an endocrine marker that can help predict superovulatory responses to treatments administered to cows for embryo production.
|Disulfide bond formation, N-Linked Glycosylation at Asn
| Site(s) of PTM(s)
|>sp|P03972|MIS_BOVIN Muellerian-inhibiting factor OS=Bos taurus OX=9913 GN=AMH PE=1 SV=1 MPGPSLSLALVLSAMGALLRPGTPREEVFSTSALPREQATGSGALIFQQAWDWPLSSLWL PGSPLDPLCLVTLHGSGN*78GSRAPLRVVGVLSSYEQAFLEAVRRTHWGLSDLTTFAVCPAG NGQPVLPHLQRLQAWLGEPGGRWLVVLHLEEVTWEPTPLLRFQEPPPGGASPPELALLVV YPGPGLEVTVTGAGLPGTQSLCLTADSDFLALVVDHPEGAWRRPGLALTLRRRGNGALLS TAQLQALLFGADSRCFTRKTPALLLLLPARSSAPMPAHGRLDLVPFPQPRASPEPEEAPP SADPFLETLTRLVRALAGPPARASPPRLALDPGALAGFPQGQVN*344LSDPAALERLLDGEEP LLLLLPPTAATTGVPATPQGPKSPLWAAGLARRVAAELQAVAAELRALPGLPPAAPPLLA RLLALCPGNPDSPGGPLRALLLLKALQGLRAEWRGRERSGSARAQRSAGAAAADGPCALR ELSVDLRAERSVLIPETYQANNCQGACGWPQSDRNPRYGNHVVLLLKMQARGATLARPPC CVPTAYTGKLLISLSEERISAHHVPNMVATECGCR
|Predicted Disorder Regions
|TM Helix Prediction
|No TM helices
|AMH levels peak in the late 20s and subsequently decline with chronologic age until becoming undetectable in the mid-to-late 40s
|1.Hawkins Bressler L, Steiner A. Anti-Müllerian hormone as a predictor of reproductive potential. Curr Opin Endocrinol Diabetes Obes. 2018 Dec;25(6):385-390. doi: 10.1097/MED.0000000000000440. PMID: 30299431. 2.. Almog B, Shehata F, Suissa S, et al. Age-related normograms of serum antimullerian hormone levels in a population of infertile women: a multicenter study. Fertil Steril 2011; 95:2359–2363; 63 e1. 3.Bleil ME, Gregorich SE, Adler NE, et al. Race/ethnic disparities in reproductive age: an examination of ovarian reserve estimates across four race/ethnic groups of healthy, regularly cycling women. Fertil Steril 2014; 101:199–207.