Primary Information |
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| BoMiProt ID | Bomi7232 |
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| Protein Name | mRNA-decapping enzyme 1B |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SZL6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001029639.1 |
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| Aminoacid Length | 581 |
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| Molecular Weight | 62880 |
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| FASTA Sequence |
Download |
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| Gene Name | DCP1B |
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| Gene ID | 514548 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Decapping enzymes.Participate in degradation of mRNAs both in normal mRNA turnover and in nonsense-mediated mRNA decay. |
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| Biochemical Properties | Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3SZL6|DCP1B_BOVIN mRNA-decapping enzyme 1B OS=Bos taurus OX=9913 GN=DCP1B PE=2 SV=1
MAVAGGPAGKGRDISLAALRRHDPYISRIVDVASQVALYTFGHRANEWEKTDVEGTLFVY
SRSASPKHGFTIMNRLSMENRTEPITKDLDFLLQDPFLLYRNARLSIYGIWFYDKEECQR
IAELMKNLTQYEQLKAHHGTGAGAS*145PVSLGSGEGKEADILRMLTKAKDEYTKCKTCSEPK
QISSSSAIHDNPNLIKPIPVKPSGSRQQRGPRPGQTSDPEPQHLSLTALFGKQDKAPCQE
ATGPPQTLPLQQQQPEKFPMRQGVVRSLS*269YEEPRRPSPPVDKQLCPAIQKLMVRSMDLQP
LAELPESRPCTDALRAACAGPAQT*324GSPRSHALAAPGTQKLLQVQSIPGAENRCEPGAPAP
ASSATT*366PVSLAQPTRLSSALPPQTPGPRALPRPAPPGPGPGHQPVTGPGEVS*412PRELLRRL
QAVQQEQQLPAPGRPALAAKFPTATLSTRARNPLEPWRDPPPSTEQPAPLLQVLS*475PQRIP
AAATPPPLMSPLVFAQPSWAPPQERSRAPLPPGNQDPAATPTGLLLPLRTPEPPGTPGSA
LSKLQLQEALLHLIQNDDNFLNIIYEAYLFSLTQAAVKKTL
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| Predicted Disorder Regions | 141-152, 171-185, 196-219, 244-270, 307-315, 319-346, 362-382, 406-418, 440-461, 482-533 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Lykke-Andersen J. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol. 2002 Dec;22(23):8114-21. doi: 10.1128/MCB.22.23.8114-8121.2002. PMID: 12417715; PMCID: PMC134073. |
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