Primary Information |
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| BoMiProt ID | Bomi7213 |
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| Protein Name | Mothers against decapentaplegic homolog 1/SMAD family member 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q1JQA2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069691.2 |
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| Aminoacid Length | 465 |
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| Molecular Weight | 52250 |
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| FASTA Sequence |
Download |
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| Gene Name | SMAD1 |
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| Gene ID | 540488 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | abomasum |
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| Protein Function | Smad1 is one of the transcription factors and also a pivotal intracellular effector of the bone morphogenetic protein (BMP) family of proteins. |
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| PTMs | N-Acetylation at Meth, Phosphorylation at Ser, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q1JQA2|SMAD1_BOVIN Mothers against decapentaplegic homolog 1 OS=Bos taurus OX=9913 GN=SMAD1 PE=2 SV=1
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
PMDTNMMAPSLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
DPSNNKNRFCLGLLSNVNRNST*322IENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISS*463VS*465
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| Predicted Disorder Regions | 39-47, 140-146, 160-267, 458-462 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Phosphorylation of the C-terminal SVS motif by BMP type 1 receptor kinase activates SMAD1 by promoting dissociation from the receptor and trimerization with SMAD4.Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. |
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| Bibliography | 1.Hegarty SV, O'Keeffe GW, Sullivan AM. BMP-Smad 1/5/8 signalling in the development of the nervous system. Prog Neurobiol. 2013 Oct;109:28-41. doi: 10.1016/j.pneurobio.2013.07.002. Epub 2013 Jul 24. PMID: 23891815. 2. |
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