Primary Information
BoMiProt ID	Bomi7206
Protein Name	Monocarboxylate transporter 13
Organism	Bos taurus
Uniprot ID	Q17QR6
Milk Fraction	Whey
Ref Sequence ID	NP_001069600.1
Aminoacid Length	426
Molecular Weight	44713
FASTA Sequence	Download
Gene Name	SLC16A13
Gene ID	538855
Protein Existence Status	reviewed
Secondary Information
Protein Function	Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.pivotal role in brain energy metabolism.MCT may play a role in the intestinal absorption of nateglinide. MCT may play a role in bumetanide’s brain penetration.
Biochemical Properties	transport a small set of xenobiotics: bumetanide, nateglinide, probenecid, and prostaglandin F2α; a series of aglycone flavonoids have been identified as inhibitors.
Significance in milk	involvement in the transport of short-chain monocarboxylates, aromatic amino acids, and thyroid hormones across the mammary alveolar epithelial cells to be utilized for milk synthesis and secretion in lactating cattle.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1 disordered segment; (405-426)
DisProt Annotation
TM Helix Prediction	11TMHs; (13-31), (82-100), (107-129), (141-163), (170-192), (219-241), (248-266), (278-300),(307-329), (341-363), & (370-392)
Bibliography	1.Kirat D, Kato S. Monocarboxylate transporter genes in the mammary gland of lactating cows. Histochem Cell Biol. 2009 Oct;132(4):447-55. doi: 10.1007/s00418-009-0621-1. Epub 2009 Jul 28. PMID: 19636583. 2.Felmlee MA, Jones RS, Rodriguez-Cruz V, Follman KE, Morris ME. Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease. Pharmacol Rev. 2020 Apr;72(2):466-485. doi: 10.1124/pr.119.018762. PMID: 32144120; PMCID: PMC7062045.