Primary Information |
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| BoMiProt ID | Bomi716 |
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| Protein Name | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P56965 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001095671.1 |
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| Aminoacid Length | 285 |
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| Molecular Weight | 31289 |
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| FASTA Sequence |
Download |
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| Gene Name | DDAH1 |
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| Gene ID | 537391 |
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| Protein Existence Status | Reviewed: Experimental evidence at protein level |
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Secondary Information |
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| Protein Function | DDAH1 is the critical enzyme for ADMA (asymmetrical dimethylarginine) and L-NMMA (N(g)-monomethyl-L-arginine) degradation. |
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| PTMs | N-acetylation at Alanine,S-nitrosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| PDB ID | 2C6Z, 2CI1, 2CI3, 2CI4, 2CI5, 2CI6, 2CI7, |
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| Bibliography | Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, Chen Y. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6. doi: 10.1161/ATVBAHA.110.222638. Epub 2011 Apr 14. PMID: 21493890; PMCID: PMC3117037. |
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