Primary Information | |
---|---|
BoMiProt ID | Bomi716 |
Protein Name | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
Organism | Bos taurus |
Uniprot ID | P56965 |
Milk Fraction | Exosome |
Ref Sequence ID | NP_001095671.1 |
Aminoacid Length | 285 |
Molecular Weight | 31289 |
FASTA Sequence | Download |
Gene Name | DDAH1 |
Gene ID | 537391 |
Protein Existence Status | Reviewed: Experimental evidence at protein level |
Secondary Information | |
Protein Function | DDAH1 is the critical enzyme for ADMA (asymmetrical dimethylarginine) and L-NMMA (N(g)-monomethyl-L-arginine) degradation. |
PTMs | N-acetylation at Alanine,S-nitrosylation |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | NA |
DisProt Annotation | |
TM Helix Prediction | No TM helices |
PDB ID | 2C6Z, 2CI1, 2CI3, 2CI4, 2CI5, 2CI6, 2CI7, |
Bibliography | Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, Chen Y. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1540-6. doi: 10.1161/ATVBAHA.110.222638. Epub 2011 Apr 14. PMID: 21493890; PMCID: PMC3117037. |