Primary Information |
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| BoMiProt ID | Bomi7156 |
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| Protein Name | Mitochondrial uncoupling protein 3/Solute carrier family 25 member 9 |
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| Organism | Bos taurus |
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| Uniprot ID | O77792 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776635.1 |
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| Aminoacid Length | 311 |
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| Molecular Weight | 34206 |
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| FASTA Sequence |
Download |
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| Gene Name | UCP3/SLC25A9 |
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| Gene ID | 281563 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | expressed in skeletal muscle,mitochondrial transporter/proton channel that participate in thermiogenesis.UCP3 expression may be stimulated when a large amount of glucose or FFA influx occcurs in skeletal muscles to prevent excessive production of ATP and ADP homeostasis.plays a role in peripheral CD4+ T cell activation and differentiation towards different effector Th subsets. |
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| Biochemical Properties | six membrane-spanning α-helix,that are connected by three long matrix loops and two shorter intermembrane (IMS) space loops.N- and C-termini are located in the IMS.The protein displays a tripartite structure. |
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| Significance in milk | fatty acid metabolism |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-12, 50-54 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Tsuboyama-Kasaoka N, Ezaki O. Mitochondrial uncoupling protein 3 (UCP3) in skeletal muscle. Front Biosci. 2001 Mar 1;6:D570-4. doi: 10.2741/kasaoka. PMID: 11229874. 2.Pohl EE, Rupprecht A, Macher G, Hilse KE. Important Trends in UCP3 Investigation. Front Physiol. 2019 Apr 30;10:470. doi: 10.3389/fphys.2019.00470. PMID: 31133866; PMCID: PMC6524716. |
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