Search by BoMiProt ID - Bomi7152

Primary Information

BoMiProt ID Bomi7152
Protein Name Mitochondrial trifunctional protein, beta subunit/TP-beta/Acetyl-CoA acyltransferase/Beta-ketothiolase/3-ketoacyl-CoA thiolase
Organism Bos taurus
Uniprot IDO46629
Milk FractionWhey
Ref Sequence ID NP_776761.1
Aminoacid Length 475
Molecular Weight 51345
FASTA Sequence Download
Gene Name HADHB
Gene ID 281811
Protein Existence Status reviewed

Secondary Information

Protein Function This enzyme catalyzes the last three reactions of the mitochondrial beta-oxidation pathway.HADHB reduces cancer cell migration and invasiveness, probably acting as a tumor suppressor gene.
Biochemical Properties The β subunit, encoded by the HADHB gene that is found on chromosome 2p23.3, catalyzes the thiolase activity.
Significance in milk fatty acid oxidation
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Miyajima, H., Ouchi, Y., Sakamoto, M., Takahashi, Y., Kono, S., & Suzuki, H. (2001). Increased anaerobic glycolysis in mitochondrial trifunctional protein-deficient brain. Journal of the neurological sciences, 184(2), 197–201.