Primary Information |
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| BoMiProt ID | Bomi7149 |
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| Protein Name | Mitochondrial ribosome-associated GTPase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q4PS77 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 332 |
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| Molecular Weight | 37004 |
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| FASTA Sequence |
Download |
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| Gene Name | MTG1 |
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| Gene ID | 509768 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | a conserved ribosome assembly guanosine triphosphatase MTG1 controls mitochondrial translation by coupling mt Large subunit assembly with intersubunit bridge formation using the intrinsic GEF activity acquired by the mtSSU through mS27(GEF), a unique occurrence in translational systems. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 1-7, 273-279, 326-332 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | MTG1-silencing in human cardiomyocytes and developing zebrafish revealed early cardiovascular lesions. |
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| Bibliography | Kim HJ, Barrientos A. MTG1 couples mitoribosome large subunit assembly with intersubunit bridge formation. Nucleic Acids Res. 2018 Sep 19;46(16):8435-8453. doi: 10.1093/nar/gky672. PMID: 30085276; PMCID: PMC6144824. |
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