Search by BoMiProt ID - Bomi7144

Primary Information

BoMiProt ID Bomi7144
Protein Name Mitochondrial import inner membrane translocase subunit Tim17-B
Organism Bos taurus
Uniprot IDQ2HJE9
Milk FractionWhey
Ref Sequence ID NP_001039953.1
Aminoacid Length 172
Molecular Weight 18321
FASTA Sequence Download
Gene Name TIMM17B
Gene ID 540765
Protein Existence Status reviewed

Secondary Information

Protein Function  translocation of transit peptide-containing proteins across the mitochondrial inner membrane.Tim17 acts as the structural component of the TIM23 complex and also plays a regulatory role for the Tim23 translocase activity.
Biochemical Properties multi-subunit protein. possesses the signature PRAT motif within TM2-loop2-TM3 region and multiple GXXXG motifs within the TMs.
PTMs Disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 2 disordered segments; (1-7), (143-172)
DisProt Annotation
TM Helix Prediction 3TMHs; (19-37), (62-80), (111-133)
Bibliography Chaudhuri M, Darden C, Gonzalez FS, Singha UK, Quinones L, Tripathi A. Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator. Biomolecules. 2020 Dec 7;10(12):1643. doi: 10.3390/biom10121643. PMID: 33297490; PMCID: PMC7762337.