Primary Information |
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| BoMiProt ID | Bomi7144 |
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| Protein Name | Mitochondrial import inner membrane translocase subunit Tim17-B |
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| Organism | Bos taurus |
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| Uniprot ID | Q2HJE9 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039953.1 |
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| Aminoacid Length | 172 |
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| Molecular Weight | 18321 |
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| FASTA Sequence |
Download |
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| Gene Name | TIMM17B |
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| Gene ID | 540765 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | translocation of transit peptide-containing proteins across the mitochondrial inner membrane.Tim17 acts as the structural component of the TIM23 complex and also plays a regulatory role for the Tim23 translocase activity. |
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| Biochemical Properties | multi-subunit protein. possesses the signature PRAT motif within TM2-loop2-TM3 region and multiple GXXXG motifs within the TMs. |
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| PTMs | Disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 2 disordered segments; (1-7), (143-172) |
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| DisProt Annotation | |
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| TM Helix Prediction | 3TMHs; (19-37), (62-80), (111-133) |
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| Bibliography | Chaudhuri M, Darden C, Gonzalez FS, Singha UK, Quinones L, Tripathi A. Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator. Biomolecules. 2020 Dec 7;10(12):1643. doi: 10.3390/biom10121643. PMID: 33297490; PMCID: PMC7762337. |
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