Search by BoMiProt ID - Bomi7143

Primary Information

BoMiProt ID Bomi7143
Protein Name Mitochondrial glutamate carrier 1/Glutamate/H(+) symporter 1/Solute carrier family 25 member 22
Organism Bos taurus
Uniprot IDQ08DK4
Milk FractionWhey
Ref Sequence ID NP_001068627.1
Aminoacid Length 322
Molecular Weight 34531
FASTA Sequence Download
Gene Name SLC25A22
Gene ID 504371
Protein Existence Status reviewed

Secondary Information

Protein Function mitochondrial carriers that transport a variety of metabolites across the inner mitochondrial membrane
Biochemical Properties catalyzes either the cotransport of L-glutamate with H+ or its exchange with OH-.Pro206 and Gly236, which reside in the face of helix IV and V respectively, lining the internal channel of the carrier through which the substrate is translocated.These residues are imp for catalytic activity of transporter.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 151-169
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Molinari F, Kaminska A, Fiermonte G, Boddaert N, Raas-Rothschild A, Plouin P, Palmieri L, Brunelle F, Palmieri F, Dulac O, Munnich A, Colleaux L. Mutations in the mitochondrial glutamate carrier SLC25A22 in neonatal epileptic encephalopathy with suppression bursts. Clin Genet. 2009 Aug;76(2):188-94. doi: 10.1111/j.1399-0004.2009.01236.x. PMID: 19780765.