Primary Information |
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| BoMiProt ID | Bomi7126 |
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| Protein Name | Microtubule-associated protein 1S/MAP-1S |
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| Organism | Bos taurus |
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| Uniprot ID | A6QQ70 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095584.1 |
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| Aminoacid Length | 1066 |
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| Molecular Weight | 112472 |
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| FASTA Sequence |
Download |
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| Gene Name | MAP1S |
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| Gene ID | 527829 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | it bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation |
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| Biochemical Properties | The ubiquitously distributed MAP1S is a homologue of the exclusively neuronal distributed microtubule-associated protein 1A and 1B (MAP1A/B). MAP1A/B (LC3), a homologue of yeast autophagy-related gene 8 (ATG8), and recruited it to stable microtubules in a MAP1S and LC3 isoform-dependent mode. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QQ70|MAP1S_BOVIN Microtubule-associated protein 1S OS=Bos taurus OX=9913 GN=MAP1S PE=2 SV=1
MAATVAGSGAAEVPSSLLLVVGGECGCRGLLAYVLEELERGIRSWDIDPGVCSLDEQLKV
FVSRHSATFSSIVKGQRSLHHRGDTLETLVLLNPSDKSLCDELRNLLLDTASHKLLVLAG
PCLEETGELLLQTGGFSPRHFLQVLGDKEIRDLLASTPPPAAPPKLTITCPTFGDWARLA
PEVPGLQGVLHLRLNPPVQLPASEGLREFLEYVAESLEPPSPFELLEPPASVGLLRLARP
CCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHAGADSLPGL
NSLLRRKLAERDEAAAGGGS*320GDDRLRRLISPNLGVVFLNARAAASRLVRGEDEAELALSL
LSQLGITPVPLNRGPLPAEPTVLFQKMGVGRLDMYVLHPPSAATTDHTLASVCALLVWHP
AGPSEKVVRVLFPGCTPPARLLDGLVHLQHLGFLREPVVTPQDMAGPRRAES*472KESVASRD
SLRREGRTTVPSRPTQERPGVARKDSPRTEAPRRAEKEARPSREVKKDPRPSAPRTQPRE
VRRAASAVVSGKNVGAQVAPKTRRAPNTPRPGVPPAENGPRS*582PPSFRSGEASPPTEACSS
PAPQLVATPSQESSLDLGLSPAGEEGGSLEEKTLELLLAASTPEPCT*647PS*649PAGAQQGPTES*660
SGPLS*665LS*667PLRGGEPGPDASPTVTTPSLPAEVGSPHSTEVDESLSVSFEQVLPPPAAAASE
AGLSLPLCGPRVRRSAS*737PHDVDLCLVSPCEFEHRKAVPMAPAPVS*765PGSSNDSSARSQERA
GAPGGAEETPPTSVSESLPTLSDSDPLPAAPGTADS*816DEDTEGFGVPRRDPLPDPLKIPPP
LPTPPSICMVDPEMLPPEQARLKGGGSRTRKPLTRPSSGTTPPKATPVTAAKIKGLASGD
RASRPLSARSEPSDKGNRASLSRKPSVPKTTTRGPSGSAGSRSGGSAAPPGSPVYLDLAY
LPSGGSARLVDEEFFRRVRALCYVISGQDQHKEEGMRAVLDALLAGKQQWDRQLQVTLIP
TFDSVAMHEWYEETHTRHQALGITVLGSNSTVSMQDEAFPACKVEF
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| Predicted Disorder Regions | 522-534, 575-724, 749-841, 875-880, 909-951 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | MAP1S may play a general role in autophagy regulation in all tissues |
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| Bibliography | 1.Xie R, Nguyen S, McKeehan K, Wang F, McKeehan WL, Liu L. Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. J Biol Chem. 2011 Mar 25;286(12):10367-77. doi: 10.1074/jbc.M110.206532. Epub 2011 Jan 24. PMID: 21262964; PMCID: PMC3060490. |
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