Primary Information |
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| BoMiProt ID | Bomi7112 |
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| Protein Name | Microsomal glutathione S-transferase 2/Glutathione peroxidase MGST2 /Leukotriene C4 synthase MGST2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KJG4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069850.1 |
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| Aminoacid Length | 146 |
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| Molecular Weight | 16483 |
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| FASTA Sequence |
Download |
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| Gene Name | MGST2 |
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| Gene ID | 615552 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | cortex of kidney |
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| Protein Function | Human microsomal glutathione transferase 2 (MGST2) is a trimeric integral membrane protein that belongs to the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family. |
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| Biochemical Properties | The mammalian MAPEG members are integral membrane proteins localized to the endoplasmic reticulum and perinuclear membrane. They are 10–45% sequence identical and can be divided into three types based on primary structures. MGST1 and microsomal prostaglandin (PG) E synthase-1 (mPGES-1) constitute one type, MGST2, leukotriene C4 synthase (LTC4S) and five lipoxygenase activating protein (FLAP) a second type and MGST3 exemplifies a third type. MGST2 is most similar to LTC4S and they share 44% sequence identity. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 2TMHs; (65-87),(105-127) |
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| Bibliography | 1.Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA, Morgenstern R, Haeggström JZ, Rinaldo-Matthis A. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1365-71. doi: 10.1016/j.bbapap.2015.06.003. Epub 2015 Jun 9. PMID: 26066610. |
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