Primary Information |
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| BoMiProt ID | Bomi7111 |
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| Protein Name | Microsomal glutathione S-transferase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q64L89 |
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| Milk Fraction | Exosomes,MFGM |
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| Ref Sequence ID | NP_001007816.1 |
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| Aminoacid Length | 155 |
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| Molecular Weight | 17645 |
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| FASTA Sequence |
Download |
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| Gene Name | MGST1 |
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| Gene ID | 493719 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | Microsomal glutathione transferase 1 (MGST1) is an abundant membrane-bound glutathione transferase and peroxidase constituting 3% of the endoplasmic reticulum protein in rat liver (and 5% of the outer mitochondrial membrane).Microsomal glutathione-S-transferase 1 (Mgst1) plays a specific role in protection of cells against oxidative stress. |
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| PTMs | N6-acetylation at Lysine,Nitration |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 3TMHs; (15-37),(83-105),(131-149) |
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| Significance of PTMs | Peroxynitrite induces nitration at Tyr-93 which activates the enzyme. |
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| Additional Comments | The enzyme is overexpressed in certain tumors and support a role for the enzyme in protecting cells from cytostatic drugs. |
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| Bibliography | 1.Morgenstern R. Microsomal glutathione transferase 1. Methods Enzymol. 2005;401:136-46. doi: 10.1016/S0076-6879(05)01008-6. PMID: 16399383. 2.Sobczak M, Boczek T, Kowalski A, Wiktorska M, Niewiarowska J, Zylinska L. Downregulation of microsomal glutathione-S-transferase 1 modulates protective mechanisms in differentiated PC12 cells. J Physiol Biochem. 2014 Jun;70(2):375-83. doi: 10.1007/s13105-014-0312-9. Epub 2014 Jan 14. PMID: 24419913. 3.Morgenstern R, Zhang J, Johansson K. Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev. 2011 May;43(2):300-6. doi: 10.3109/03602532.2011.558511. PMID: 21495795. |
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