Search by BoMiProt ID - Bomi7054


Primary Information

BoMiProt ID Bomi7054
Protein Name Methylosome protein 50
Organism Bos taurus
Uniprot IDQ5E9I7
Milk FractionExosomes
Ref Sequence ID NP_001015584.1
Aminoacid Length 342
Molecular Weight 36789
FASTA Sequence Download
Gene Name WDR77
Gene ID 512993
Protein Existence Status Reviewed

Secondary Information

Protein Function Methylosome protein 50 (MEP50) is a component of methylosome where MEP50 binds protein substrates and activates the oncogenic protein arginine methyl transferase 5 (PRMT5). MEP50 is also a coactivator for androgen receptor (AR) and estrogen receptor (ER), and transforms cells in the presence of androgen or estrogen.
PTMs Phosphorylation at Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q5E9I7|MEP50_BOVIN Methylosome protein 50 OS=Bos taurus OX=9913 GN=WDR77 PE=2 SV=1 MRKET*5PPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWL FKDPCAAPNEGFCSAGVQTEAGVADLTWVGDRGILVASDSGAVELWELDENETLIVSKFC KYEHDDIVSTVSVLSSGTHAVSGSKDFCIKVWDLAQQMVLNSYRAHSGQVTCVAASPHKD SVFLSCGEDNRILLWDTRCPKPASQMGCSASGYLPTSLTWHPQQSEVFVFGDENGTVSLV DTKSAGCAVSSVVHSQCVTGLVFSPHSAPFLASVSEDCSLAVLDSGLSEVFRSRAHRDFV RDATWSPLNHSLLTTVGWDHQVIHHILPTEPLPEPGPKSAAE
Predicted Disorder Regions 1-14, 331-342
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Wei TY, Hsia JY, Chiu SC, Su LJ, Juan CC, Lee YC, Chen JM, Chou HY, Huang JY, Huang HM, Yu CT. Methylosome protein 50 promotes androgen- and estrogen-independent tumorigenesis. Cell Signal. 2014 Dec;26(12):2940-50. doi: 10.1016/j.cellsig.2014.09.014. Epub 2014 Sep 30. PMID: 25277535.