Search by BoMiProt ID - Bomi7052

Primary Information

BoMiProt ID Bomi7052
Protein Name Methylmalonyl-CoA epimerase, mitochondrial/DL-methylmalonyl-CoA racemase
Organism Bos taurus
Uniprot IDQ2KIZ3
Milk FractionWhey
Ref Sequence ID NP_001039460.1
Aminoacid Length 175
Molecular Weight 18514
FASTA Sequence Download
Gene Name MCEE
Gene ID 508170
Protein Existence Status reviewed

Secondary Information

Protein Function Methylmalonyl-CoA epimerase (MCE) is an enzyme involved in the propionyl-CoA metabolism that is responsible for the degradation of branched amino acids and odd-chain fatty acids.
Biochemical Properties This protein is involved in the flow of D-methylmalonyl-CoA to L-methylmalonyl-CoA----tricarboxylic acid cycle
PTMs Acetylation at Lys
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-6, 21-37, 108-114
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments The sequence similarity to an MCE of known structure was high enough to permit a three-dimensional model to be built, suggesting conservation of ligand and metal binding sites. Comparison with corresponding sequences from a variety of organisms shows more than 1/6 of the sequence is completely conserved.
Bibliography 1.Stabler SP, Marcell PD, Allen RH. Isolation and characterization of DL-methylmalonyl-coenzyme A racemase from rat liver. Arch Biochem Biophys. 1985 Aug 15;241(1):252-64. doi: 10.1016/0003-9861(85)90381-9. PMID: 2862845. 2.Kühnl J, Bobik T, Procter JB, Burmeister C, Höppner J, Wilde I, Lüersen K, Torda AE, Walter RD, Liebau E. Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans. FEBS J. 2005 Mar;272(6):1465-77. doi: 10.1111/j.1742-4658.2005.04579.x. PMID: 15752362.