Primary Information |
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| BoMiProt ID | Bomi7047 |
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| Protein Name | Methionine synthase reductase(MSR)/Aquacobalamin reductase(AqCbl reductase) |
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| Organism | Bos taurus |
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| Uniprot ID | Q4JIJ2 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001025470.1 |
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| Aminoacid Length | 695 |
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| Molecular Weight | 77163 |
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| FASTA Sequence |
Download |
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| Gene Name | MTRR |
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| Gene ID | 507991 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Methionine synthase reductase (MTRR) plays a major role in hyperhomocysteinemia, a risk factor related to the occurrence of congenital heart defects (CHDs). |
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| Biochemical Properties | Methionine synthase reductase (MTRR) is required for the reductive methylation of cobalamin, which is the functional cofactorial form of methionine synthase (MS) in the remethylation of homocysteine to methionine. |
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| PTMs | Phosphorylation at Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q4JIJ2|MTRR_BOVIN Methionine synthase reductase OS=Bos taurus OX=9913 GN=MTRR PE=2 SV=1
MRRFLLLYATQRGQAKAIAEEISEKAVTYGFSADLHCISESDKYDLKTETAPLVMVVSTT
GNGDPPDTARKFVKAIKDKTLPPDFLAHLRYGLLGLGDSEYTYFCNGGKVIDKRLQELGA
QRFYDTGHADDCVGLELVVEPWINGLWAALEKHFLSNRGREDTSETLTMAS*171HASRDAVTP
ELLHVES*187QVGLLKLDDSGGKAAKVLEQNAVNSNQSSTLIVDFEASLTHSVPPLSQASLNI
PSLPPEYLEVHLEEALGQEESHASVSLVDPVFHVPVSKAVQLTTNDAIKTTLLIELDISK
TDFSYQPGDAFNVICPNSDSEVQFLLQRLQLADRREHHVAVTIKADTRKKGAALPQHVPE
RCSLQFLLTWCLEIRAVPKKAFLRALADHTGDSAERRRLQELCSRQGAADYTRFVREAGA
CLSDLLRAFPSCQPPLGLLLEHLPKLQPRPYSCASSSLFHPGKLHFIFNIVEFLSNTTEV
ILRRGVCTGWLATLVESILQPYMCANHVDGKKALAPKISISPRTTNSFHLPDDPSVPIIM
VGPGAGVAPFIGFLQHREKLQEQHPGGHFGATWLFFGCRHKERDYLFRDELRHFLKCGVL
THLEVSFSRDVAVGEEEGPAKYVQDSLQRHSKQVAGVLLQDSGYVYVCGDAKNMAKDVHD
ALVEIISRETGVEKLEAMKTLATLKEEKRYLQDIW
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | Methionine synthase reductase A66G polymorphism is associated with decreased risk of leukemia in a Caucasian population and in children, especially for ALL. |
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| Bibliography | 1.Fang DH, Ji Q, Fan CH, An Q, Li J. Methionine synthase reductase A66G polymorphism and leukemia risk: evidence from published studies. Leuk Lymphoma. 2014 Aug;55(8):1910-4. doi: 10.3109/10428194.2013.867492. Epub 2014 Jan 24. PMID: 24261678. 2.Yu D, Yang L, Shen S, Fan C, Zhang W, Mo X. Association between methionine synthase reductase A66G polymorphism and the risk of congenital heart defects: evidence from eight case-control studies. Pediatr Cardiol. 2014 Oct;35(7):1091-8. doi: 10.1007/s00246-014-0948-9. Epub 2014 Jun 10. PMID: 24913415. |
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