Primary Information
BoMiProt ID	Bomi7027
Protein Name	Mesencephalic astrocyte-derived neurotrophic factor/Arginine-rich protein/Protein ARMET
Organism	Bos taurus
Uniprot ID	P80513
Milk Fraction	Whey
Ref Sequence ID	NP_001094681.1
Aminoacid Length	179
Molecular Weight	20357
FASTA Sequence	Download
Gene Name	MANF
Gene ID	540432
Protein Existence Status	Reviewed
Secondary Information
Presence in other biological fluids/tissue/cells	spermatocyte
Protein Function	Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of activated B cells (NF-κB) p65.
PTMs	Disulfide bond formation, Phosphorylation at Ser
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|P80513|MANF_BOVIN Mesencephalic astrocyte-derived neurotrophic factor OS=Bos taurus OX=9913 GN=MANF PE=1 SV=2 MWATHGLAVALALSVLPASRALRQGDCEVCISYLGRFYQDLKDRDVTFSPASIEKELIKF CREARGKENRLCY*73YIGATEDAATKIINEVSKPLSHHIPVEKICEKLKKKDSQICELKYDK QIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASSRTDL
Predicted Disorder Regions	98-116, 125-133, 168-179
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Liu J, Wu Z, Han D, Wei C, Liang Y, Jiang T, Chen L, Sha M, Cao Y, Huang F, Geng X, Yu J, Shen Y, Wang H, Feng L, Wang D, Fang S, Wang S, Shen Y. Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Liver Cancer Through Small Ubiquitin-Related Modifier (SUMO)ylation-Related Suppression of NF-κB/Snail Signaling Pathway and Epithelial-Mesenchymal Transition. Hepatology. 2020 Apr;71(4):1262-1278. doi: 10.1002/hep.30917. Epub 2020 Jan 26. PMID: 31469428; PMCID: PMC7187412.