Primary Information |
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| BoMiProt ID | Bomi7024 |
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| Protein Name | Menin |
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| Organism | Bos taurus |
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| Uniprot ID | Q0P5I0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069629.1 |
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| Aminoacid Length | 610 |
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| Molecular Weight | 67384 |
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| FASTA Sequence |
Download |
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| Gene Name | MEN1 |
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| Gene ID | 539431 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ubiquitously expressed in all tissues examined, including bone.It is related to various cellular functions, such as transcriptional regulation, DNA replication, DNA repair, cell cycle and cell differentiationacts as tumor suppressor.Menin is considered to support BMP-2- and Runx2-induced differentiation of mesenchymal cells into osteoblasts by interacting with Smad1/5, Runx2, β-catenin and LEF-1. |
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| Biochemical Properties | 610-amino-acid protein,two nuclear localization signal sequences are identified at the carboxyl-terminal portion of this protein.Also contains two leucine zipper-like motifs (LZM).menin is required for adipocyte differentiation by augmenting peroxisome proliferator-activated receptor gamma (PPARγ) target gene expression through recruitment of H3K4 methyltransferase activity. |
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| Significance in milk | regulates milk protein synthesis through mTOR signaling in mammary epithelial cells |
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| PTMs | Phosphorylation on Ser and Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0P5I0|MEN1_BOVIN Menin OS=Bos taurus OX=9913 GN=MEN1 PE=2 SV=1
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQTQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRES*487KPEEPPPPKKPALDKGPGAGQGAVPGPPRKPPGTVPGTARGAEGGSAAPVPAP
AAS*543PPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVST*594PSDYTL
SFLKRQRKGL
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| Predicted Disorder Regions | 65-69, 199-206, 385-403, 476-488, 529-554, 566-601 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Significance of PTMs | menin is specifically phosphorylated at Ser394 in response to several forms of DNA damage.Ser487 is dynamically phosphorylated and Ser543 is constitutively phosphorylated. |
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| Bibliography | 1.Kaji H. Menin and bone metabolism. J Bone Miner Metab. 2012 Jul;30(4):381-7. doi: 10.1007/s00774-012-0355-3. Epub 2012 Apr 28. PMID: 22543820. 2.Francis J, Lin W, Rozenblatt-Rosen O, Meyerson M. The menin tumor suppressor protein is phosphorylated in response to DNA damage. PLoS One. 2011 Jan 14;6(1):e16119. doi: 10.1371/journal.pone.0016119. PMID: 21264250; PMCID: PMC3021530. |
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