Primary Information
BoMiProt ID	Bomi7009
Protein Name	Melanoma-associated antigen D4/MAGE-D4 antigen
Organism	Bos taurus
Uniprot ID	A6QLI5
Milk Fraction	Whey
Ref Sequence ID	NP_001096781.1
Aminoacid Length	740
Molecular Weight	81527
FASTA Sequence	Download
Gene Name	MAGED4
Gene ID	100125231
Protein Existence Status	reviewed
Secondary Information
Protein Function	A potential biomarker for glioma and an important prognostic factor for patients with new or recurring glioma.It's overexpression influences tumor progression, and MADE-D4 can be a prognostic marker and a potential molecular target in squamous cell EC.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	1-12, 95-354, 369-382, 699-723
DisProt Annotation
TM Helix Prediction	no TM helices
Additional Comments	MAGE-D4 critically contributes to breast cancer tumorigenesis by regulating anchorage-independent growth, motility, and invasiveness.
Bibliography	1.Yan J, Wen J, Wei ZD, Li XS, Li P, Xiao SW. Prognostic and clinicopathological value of melanoma-associated antigen D4 in patients with glioma. Oncol Lett. 2018 Apr;15(4):4151-4160. doi: 10.3892/ol.2018.7884. Epub 2018 Jan 26. PMID: 29541180; PMCID: PMC5835852. 2.Oya H, Kanda M, Takami H, Hibino S, Shimizu D, Niwa Y, Koike M, Nomoto S, Yamada S, Nishikawa Y, Asai M, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y. Overexpression of melanoma-associated antigen D4 is an independent prognostic factor in squamous cell carcinoma of the esophagus. Dis Esophagus. 2015 Feb-Mar;28(2):188-95. doi: 10.1111/dote.12156. Epub 2013 Oct 21. PMID: 24147998.