Primary Information |
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| BoMiProt ID | Bomi6916 |
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| Protein Name | Lysyl oxidase homolog 2/Lysyl oxidase-like protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | A6H737 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001092523.1 |
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| Aminoacid Length | 774 |
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| Molecular Weight | 86785 |
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| FASTA Sequence |
Download |
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| Gene Name | LOXL2 |
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| Gene ID | 532684 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | ritical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma |
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| Biochemical Properties | Not only that LOXL2 was regulated by hypoxia/hypoxia-inducible factor 1 alpha (HIF-1α), but also that TGF-β activated LOXL2 transcription through mothers against decapentaplegic homolog 4 (Smad4), whereas two frequently underexpressed miRNA families, miR-26 and miR-29, cooperatively suppressed LOXL2 transcription through interacting with the 3' untranslated region of LOXL2. |
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| Significance in milk | Ordered Collagen Fibrillogenesis |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6H737|LOXL2_BOVIN Lysyl oxidase homolog 2 OS=Bos taurus OX=9913 GN=LOXL2 PE=2 SV=1
MERRGSSCLCRCLALLALLPTLSLAQYESWRHYPEYFQEPAPEYHRPEVPSDVAKIQLRL
AGQKRKHSEGRVEVYYDGQWGTVCDDDFTIHAAHVVCRELGYVEAKSWTASSSYGKGEGP
IWLDNVYCTGSEATLAACSSNGWGVTDCKHTEDVGVVCSEKRIPGFKFDNSLINSIENMN
IQVEDIRIRAILSAFRKRTPVTEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGEK
TYNTKVYKMFAARKKQRYWPYSMDCTGTEAHISSCKLGPQVSLDPVKN*288VTCENGLPAVVS
CVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGANVGEGRVEVLKNGEWGTVCDDKWDLVSA
SVVCRELGFGSAKEAITGSRLGQGIGPIHLNEIECTGNEKSIIDCKFNAESQGCNHEEDA
AVRCNIPAMGFQKKLRLNGGRNPYEGRVEVLVERN*455GSLVWGMVCGENWGIVEAMVVCRQL
GLGFASNAFQETWYWHGNINANKVVMSGVKCSGTELSLAHCRHDGEDVACPEGGVRYGAG
VACSETAPDLVLNAEIVQQSTYLEDRPMFMLQCAMEENCLSASAAQTNPTTGYRRLLRFS
SQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLN*644GTKVAEGHKASFCLED
TECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNYEV
AESDYTNNIMKCRTRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLINNQVSKR
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Additional Comments | Overexpression of LOXL2, an important driver of HCC metastasis. |
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| Bibliography | 1.Wong CC, Tse AP, Huang YP, Zhu YT, Chiu DK, Lai RK, Au SL, Kai AK, Lee JM, Wei LL, Tsang FH, Lo RC, Shi J, Zheng YP, Wong CM, Ng IO. Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology. 2014 Nov;60(5):1645-58. doi: 10.1002/hep.27320. Epub 2014 Oct 2. PMID: 25048396. |
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