Primary Information |
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| BoMiProt ID | Bomi6915 |
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| Protein Name | Lysyl oxidase homolog 1/Lysyl oxidase-like protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q95L39 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776808.1 |
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| Aminoacid Length | 591 |
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| Molecular Weight | 64496 |
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| FASTA Sequence |
Download |
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| Gene Name | LOXL1 |
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| Gene ID | 281903 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | mainly located in smooth muscle cells and fibroblasts |
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| Protein Function | elastic fiber formation and remodeling.catalyse the covalent cross-linking of collagen and elastin through oxidative deamination of lysine or hydroxylysine side chains, particularly during dynamic processes such as development, tissue injury, fibrosis, and cancer |
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| Biochemical Properties | belongs to lysyl oxidase family oxidise amine to reactive aldehydes.Highly conserved c terminal region called copper binding catalytic domain which is responsible for converting primary amines of side chains of lysine into reactive aldehydes.N-terminal regions, which are important for substrate binding and enzyme maturation. |
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| PTMs | disulfide bond formation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 25-38, 94-98, 120-123, 146-148, 160-192, 233-256, 285-290, 302-309 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Schlötzer-Schrehardt U, Zenkel M. The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma. Exp Eye Res. 2019 Dec;189:107818. doi: 10.1016/j.exer.2019.107818. Epub 2019 Sep 26. PMID: 31563608. |
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