Search by BoMiProt ID - Bomi6910

Primary Information

BoMiProt ID Bomi6910
Protein Name Lysophospholipid acyltransferase 5/1-acylglycerophosphocholine O-acyltransferase/1-acylglycerophosphoethanolamine O-acyltransferase/1-acylglycerophosphoserine O-acyltransferase/Lysophosphatidylcholine acyltransferase 3/Membrane-bound O-acyltransferase domain-containing protein 5
Organism Bos taurus
Uniprot IDQ3SZL3
Milk FractionWhey
Ref Sequence ID NP_001019717.2
Aminoacid Length 485
Molecular Weight 55834
FASTA Sequence Download
Gene ID 515361
Protein Existence Status reviewed

Secondary Information

Protein Function Phospholipid remodeling and limiting the abundance of bioactive lipids.LPCAT3 also regulates cell growth and apoptosis.
Biochemical Properties lysophosphatidylcholine acyltransferase 3 (LPCAT3) is the characterization of a human homolog of LPT1.
Significance in milk catalyses reacylation of LPC( lysophosphatidylcholine) with a second fatty acid (in the form of fatty acyl-CoA)
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 472-485
DisProt Annotation
TM Helix Prediction 9TMHs; (42-60), (67-85), (104-126), (139-157), (176-198),(277-299), (358-380), (425-443), and (452-470)
Additional Comments Reduced LPCAT3 activity disrupts Golgi structure, limiting plasma membrane extension and cell proliferation.
Bibliography 1.Jain S, Zhang X, Khandelwal PJ, Saunders AJ, Cummings BS, Oelkers P. Characterization of human lysophospholipid acyltransferase 3. J Lipid Res. 2009 Aug;50(8):1563-70. doi: 10.1194/jlr.M800398-JLR200. Epub 2009 Apr 7. PMID: 19351971; PMCID: PMC2724057.