Primary Information |
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| BoMiProt ID | Bomi6910 |
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| Protein Name | Lysophospholipid acyltransferase 5/1-acylglycerophosphocholine O-acyltransferase/1-acylglycerophosphoethanolamine O-acyltransferase/1-acylglycerophosphoserine O-acyltransferase/Lysophosphatidylcholine acyltransferase 3/Membrane-bound O-acyltransferase domain-containing protein 5 |
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| Organism | Bos taurus |
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| Uniprot ID | Q3SZL3 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001019717.2 |
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| Aminoacid Length | 485 |
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| Molecular Weight | 55834 |
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| FASTA Sequence |
Download |
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| Gene Name | LPCAT3/MBOAT5/ OACT5 |
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| Gene ID | 515361 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Phospholipid remodeling and limiting the abundance of bioactive lipids.LPCAT3 also regulates cell growth and apoptosis. |
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| Biochemical Properties | lysophosphatidylcholine acyltransferase 3 (LPCAT3) is the characterization of a human homolog of LPT1. |
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| Significance in milk | catalyses reacylation of LPC( lysophosphatidylcholine) with a second fatty acid (in the form of fatty acyl-CoA) |
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| PTMs | Acetylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 472-485 |
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| DisProt Annotation | |
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| TM Helix Prediction | 9TMHs; (42-60), (67-85), (104-126), (139-157), (176-198),(277-299), (358-380), (425-443), and (452-470) |
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| Additional Comments | Reduced LPCAT3 activity disrupts Golgi structure, limiting plasma membrane extension and cell proliferation. |
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| Bibliography | 1.Jain S, Zhang X, Khandelwal PJ, Saunders AJ, Cummings BS, Oelkers P. Characterization of human lysophospholipid acyltransferase 3. J Lipid Res. 2009 Aug;50(8):1563-70. doi: 10.1194/jlr.M800398-JLR200. Epub 2009 Apr 7. PMID: 19351971; PMCID: PMC2724057. |
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