Search by BoMiProt ID - Bomi691

Primary Information

BoMiProt ID Bomi691
Protein Name Coatomer subunit gamma
Organism Bos taurus
Uniprot IDP53620
Milk FractionExosome
Ref Sequence ID NP_001032904.1
Aminoacid Length 874
Molecular Weight 97386
FASTA Sequence Download
Gene Name COPG1
Gene ID 338055
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondary Information

Protein Function export proteins from the endoplasmic reticulum; retrograde transport of luminal and membrane proteins in the ER-Golgi segment of the secretory pathway; play a role in the correct steady-state distribution of proteins within the Golgi stack. alpha-COPI was found to be required for the formation of RER whorls in midgut epithelial cells of unfed Aa. aegypti mosquitoes, as well as for the expression of late phase midgut proteases.
Biochemical Properties involves members of a family of 23–24 kD type-I transmembrane proteins (the p24 family) that are sorted into coat protein (COPI) vesicles where they become a major constituent; COPI subunits of the cytosolic coatomer complex exhibit significant structural heterogeneity; ß-COP exists as three to five distinct species, while δ-COP exists as up to three species with differing pI but identical molecular weights; Ɣ-COP - pI ;5.9
PTMs As observed in rat liver, ß and δ-COP are phosphorylated
Significance of PTMs Phosphorylation probably alter solubility characteristics
Linking IDs Bomi51
Bibliography 1. Tu, L., Tai, W. C. S., Chen, L., & Banfield, D. K. (2008). Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science (New York, N.Y.), 321(5887), 404–407.
2. Cosson, P., & Letourneur, F. (1994). Coatomer interaction with di-lysine endoplasmic reticulum retention motifs. Science (New York, N.Y.), 263(5153), 1629–1631.
3. Letourneur, F., Gaynor, E. C., Hennecke, S., Démollière, C., Duden, R., Emr, S. D., … Cosson, P. (1994). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell, 79(7), 1199–1207.
4. Sohn, K., Orci, L., Ravazzola, M., Amherdt, M., Bremser, M., Lottspeich, F., … Wieland, F. T. (1996). A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. The Journal of Cell Biology, 135(5), 1239–1248.
5. Stamnes, M. A., Craighead, M. W., Hoe, M. H., Lampen, N., Geromanos, S., Tempst, P., & Rothman, J. E. (1995). An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proceedings of the National Academy of Sciences of the United States of America, 92(17), 8011–8015.
6 Sheff, D., Lowe, M., Kreis, T. E., & Mellman, I. (1996). Biochemical heterogeneity and phosphorylation of coatomer subunits. The Journal of Biological Chemistry, 271(12), 7230–7236. 7.Zhou G, Isoe J, Day WA, Miesfeld RL. Alpha-COPI coatomer protein is required for rough endoplasmic reticulum whorl formation in mosquito midgut epithelial cells. PLoS One. 2011 Mar 31;6(3):e18150. doi: 10.1371/journal.pone.0018150. PMID: 21483820; PMCID: PMC3069061.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-19,587-607,739-748
DisProt Annotation
TM Helix Prediction No TM helices