Search by BoMiProt ID - Bomi691


Primary Information

BoMiProt ID Bomi691
Protein Name Coatomer subunit gamma
Organism Bos taurus
Uniprot IdP53620
Milk FractionExosome
Ref Sequence Id NP_001032904.1
Amino Acid Lenth 874
Molecular Weight 97386
Fasta Sequence https://www.uniprot.org/uniprot/P53620.fasta
Gene Name COPG1
Gene Id 338055
Protein Existence Status Reveiwed:Experimental evidence at protein level

Secondry Information

Protein Function export proteins from the endoplasmic reticulum; retrograde transport of luminal and membrane proteins in the ER-Golgi segment of the secretory pathway; play a role in the correct steady-state distribution of proteins within the Golgi stack
Biochemical Properties involves members of a family of 23–24 kD type-I transmembrane proteins (the p24 family) that are sorted into coat protein (COPI) vesicles where they become a major constituent; COPI subunits of the cytosolic coatomer complex exhibit significant structural heterogeneity; ß-COP exists as three to five distinct species, while δ-COP exists as up to three species with differing pI but identical molecular weights; Ɣ-COP - pI ;5.9
PTMs As observed in rat liver, ß and δ-COP are phosphorylated
Significance of PTMs Phosphorylation probably alter solubility characteristics
PDB ID 3MKR,
Linking IDs Bomi51
Bibliography 1. Tu, L., Tai, W. C. S., Chen, L., & Banfield, D. K. (2008). Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science (New York, N.Y.), 321(5887), 404–407. https://doi.org/10.1126/science.1159411.
2. Cosson, P., & Letourneur, F. (1994). Coatomer interaction with di-lysine endoplasmic reticulum retention motifs. Science (New York, N.Y.), 263(5153), 1629–1631. https://doi.org/10.1126/science.8128252.
3. Letourneur, F., Gaynor, E. C., Hennecke, S., Démollière, C., Duden, R., Emr, S. D., … Cosson, P. (1994). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell, 79(7), 1199–1207. https://doi.org/10.1016/0092-8674(94)90011-6.
4. Sohn, K., Orci, L., Ravazzola, M., Amherdt, M., Bremser, M., Lottspeich, F., … Wieland, F. T. (1996). A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. The Journal of Cell Biology, 135(5), 1239–1248. https://doi.org/10.1083/jcb.135.5.1239.
5. Stamnes, M. A., Craighead, M. W., Hoe, M. H., Lampen, N., Geromanos, S., Tempst, P., & Rothman, J. E. (1995). An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding. Proceedings of the National Academy of Sciences of the United States of America, 92(17), 8011–8015. https://doi.org/10.1073/pnas.92.17.8011.
6 Sheff, D., Lowe, M., Kreis, T. E., & Mellman, I. (1996). Biochemical heterogeneity and phosphorylation of coatomer subunits. The Journal of Biological Chemistry, 271(12), 7230–7236. https://doi.org/10.1074/jbc.271.12.7230.