Primary Information
BoMiProt ID	Bomi6890
Protein Name	Lymphocyte transmembrane adapter 1/Membrane-associated adapter protein LAX
Organism	Bos taurus
Uniprot ID	Q58CT8
Milk Fraction	Whey
Ref Sequence ID	NP_001015674.1
Aminoacid Length	387
Molecular Weight	41859
FASTA Sequence	Download
Gene Name	LAX1
Gene ID	540424
Protein Existence Status	reviewed
Secondary Information
Protein Function	Negatively regulates T-cell antigen receptor-mediated signaling and B-cell antigen receptor-mediated signaling in T-cell and B-cells respectively.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q58CT8|LAX1_BOVIN Lymphocyte transmembrane adapter 1 OS=Bos taurus OX=9913 GN=LAX1 PE=2 SV=1 MDVTTSAWSETTRRISEPSTLQGTLGSLDKAEDHSSSIFSGFAALLAILLVVAVICVLWC CGKRKKRQVPYLRVTIMPLLTLPRPRQRAKNIYDLLPRRQEELGRHPSRSIRIVSTESLL SRNSDSPSSEHVPSRAGDALHMHRAHTHAMGYAVGIYDNAMRPQMCGNLAPSPHYVNVRA SRGSPSTSSEDSRDY*195VNIPTAKEIAETLASASNPPRNLFILPGTKELAPSEEIDEGCGNA SDCTSLGSPGTENSDPLSDGEGSSQTSNDY*270VNMAELDLGTPQGKQLQGMFQCRRDY*296ENVP PGPSSNKQQEEEVTSSNTDHVEGRTDGPETHTPPAVQSGSFLALKDHVACQSSAHSETGP WEDAEETSSEDSHDY*375ENVCAAEAGARG
Predicted Disorder Regions	(1-28), (99-106), (115-141), (178-387)
DisProt Annotation
TM Helix Prediction	1TMH; (38-60)
Significance of PTMs	Upon T cell or B cell Recpetor activation, phosphorylation on tyrosines occurs which leads to the recruitment of GRB2, PIK3R1 and GRAP2
Bibliography	Harhay, G. P., Sonstegard, T. S., Keele, J. W., Heaton, M. P., Clawson, M. L., Snelling, W. M., Wiedmann, R. T., Van Tassell, C. P., & Smith, T. P. (2005). Characterization of 954 bovine full-CDS cDNA sequences. BMC genomics, 6, 166. https://doi.org/10.1186/1471-2164-6-166