Primary Information |
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| BoMiProt ID | Bomi6868 |
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| Protein Name | Long-chain-fatty-acid--CoA ligase ACSBG1/Acyl-CoA synthetase bubblegum family member 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q2KHW5 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001019719.1 |
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| Aminoacid Length | 726 |
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| Molecular Weight | 80585 |
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| FASTA Sequence |
Download |
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| Gene Name | ACSBG1 |
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| Gene ID | 515577 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | A new membrane-associated acyl-CoA synthetase (ACS), termed bubblegum-related protein (BGR), which upon functional analysis demonstrated ACS activity capable of activating long- and very long-chain fatty acids. |
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| Biochemical Properties | BGR cDNA encoding a protein with broad overall homology to the human BGM protein with 50% identical and 68% similar amino acids. The protein exhibits several features of an ACS, namely an AMP-binding motif and a fatty acidbinding motif common to all bubblegum orthologs characterized so far and which exhibits slight homology to known ACSVL motifs. |
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| Significance in milk | role in bovine milk fat synthesis during the lactation cycle |
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| PTMs | Phosphorylation at Ser/Tyr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2KHW5|ACBG1_BOVIN Long-chain-fatty-acid--CoA ligase ACSBG1 OS=Bos taurus OX=9913 GN=ACSBG1 PE=2 SV=1
MPDSRAAPQESLLDASLGTTQENVGTSSLTDGQTLS*36KEPLSHALKLSTPEKVKDAQLNPP
EEALWTTRADGRVRLRIDPICSQTPRTVHQMFSTTLDKYGDLSAMGFKRQGTWEHISYTQ
YYLLARKAAKGFLKLGLERAHSVAILAFNSPEWFFSAVGAVFGGGIITGIYTTSSPEACQ
YIAYDCRANIIVVDTQKQLEKILKIWKHLPHLKAVVIYREAPPMRMPSVYTMEELMELGN
EVPEEALDVIINAQKPNQCCALVYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEI
QQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSLVNTLREVEPTSHMGVPR
VWEKIMEQIQEVAAQSGFIWRKMLLWAMSVTLEQNLTCPSSDLKPFTTRLADYLVLAKVR
QALGFAKCQKNFYGAAPMTAETQHFFLGLNIRLYAGYGLSETSGPHFMSSPYNYRLYSSG
KVVPGCQVKLVNEDAEGIGEICLWGRTIFMGYLNMEDKTCEAIDAEGWLHTGDTGRLDAD
GFLYITGRLKELIITAGGENVPPVPIEEAVKTELPIIRNAMLIGDQRKFLSMLLTLKCTL
DPDTFEPTDNLTEQAVEFCQRVGSKATTVSEVVGKKDEAVY*641QAIEEGIQRVNMNAAARPY
HIQKWAILEKDFSISGGELGPTMKLKRLAVLEKYKDVIDSFYQEQKSKQGSSLPGFSLRW
QTGASS
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| Predicted Disorder Regions | (1-62), (709-726) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | The BGM enzyme shares several features with other ACSs: (i) it is able to activate LCFA and VLCFA; and (ii) shows a distinct tissue distribution |
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| Bibliography | 1.Fraisl P, Tanaka H, Forss-Petter S, Lassmann H, Nishimune Y, Berger J. A novel mammalian bubblegum-related acyl-CoA synthetase restricted to testes and possibly involved in spermatogenesis. Arch Biochem Biophys. 2006 Jul 1;451(1):23-33. doi: 10.1016/j.abb.2006.04.013. Epub 2006 May 8. PMID: 16762313. 2. P.A. Watkins, Prog. Lipid Res. 36 (1997) 55–83. 3. S.J. Steinberg, J. Morgenthaler, A.K. Heinzer, K.D. Smith, P.A. Watkins, J. Biol. Chem. 275 (2000) 35162–35169. |
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