Primary Information |
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| BoMiProt ID | Bomi6834 |
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| Protein Name | Little elongation complex subunit 2/Interactor of little elongator complex ELL subunit 2/NMDA receptor-regulated protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q0VCQ7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069733.1 |
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| Aminoacid Length | 981 |
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| Molecular Weight | 109914 |
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| FASTA Sequence |
Download |
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| Gene Name | ICE2/NARG2 |
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| Gene ID | 541255 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes. |
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| PTMs | Phosphorylation at Ser/Thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q0VCQ7|ICE2_BOVIN Little elongation complex subunit 2 OS=Bos taurus OX=9913 GN=ICE2 PE=2 SV=1
MTSMMAMGEPRLNWDVS*17PKNGLKTFFSRENYKDQSMAPSLKELCILSSRRIGENLNASAG
SVENEPTVNSAAQAKEKVKTTVGMVLLPKPRVPYPRFSRFSQREQRNYVDLLVKYAKVPP
NSKTVGINKNDYLQYLEMKKHVNEEVTEFLKFLQNSAKKCAQDYNMLSDDACLVTEQILK
ACIEQVKKYPEFYTLHEVTSLMGFFPFRIEMGFKLEKTLLALGSVKYVKTVFPSMPAKLQ
LSKDTIPAIETPEQIAAAMHYDISEDPNAEKLVARYHPQIALTSQSLFTLLNNHGPSYKE
QWEIPVCIQVIPVAGSKPIKVIYINS*326PLPQKKMTMRERNQIFHEVPLKFMMSKNTSVPVS
AVFMDKPEEYISEMDISYEVNECRKIETLENLDLEFDDDVTELETFGATTTKPSKSPSPA
STSTVAPMTDTLTAPSIADTSEAPTSPDISAHSRSLSQILMEQLQKEKQLVTGMIDSGPE
ESKNKDDQRFIPCGEKVSNSDKPLVQDSDLKTSDPLQLESSMEIETSSKNDMATEMESVD
ERVNVLENTDTNSKEKTVTSEAANTEDVVLDSS*573DT*575DEDCLIIDMECQSNSHGKTAEVGSN
LSSKPASLNSSSGQTSTGNQTNSTCPEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPI
SRKIPELPLMNSENSKQPPISEQPSAPSDACSWPKSIWPSAFQKPKGRLPYELQDYVEDT
SEYVAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQA
CYGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKIS
SLFNILQHILRKLSSLQEGSYLLSHAAEDSSLLIYKTSDGKVTRTAYNLHKTHCGLPGVP
SSLSVPWVPLDPSLLLPNHIHHGRIPCTFPPKSLGPTAQQKIGGTRMPTRSHRNSVSVET
KSLPAQQVENEGVASSKRKIT
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| Predicted Disorder Regions | 59-73, 409-456, 491-622, 680-689, 757-760, 975-981 |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | 1.Takahashi H, Takigawa I, Watanabe M, Anwar D, Shibata M, Tomomori-Sato C, Sato S, Ranjan A, Seidel CW, Tsukiyama T, Mizushima W, Hayashi M, Ohkawa Y, Conaway JW, Conaway RC, Hatakeyama S. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. Nat Commun. 2015 Jan 9;6:5941. doi: 10.1038/ncomms6941. PMID: 25575120; PMCID: PMC4646223. |
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