Primary Information |
|---|
| BoMiProt ID | Bomi6814 |
|---|
| Protein Name | LIM domain-containing protein ajuba |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | E1BKA3 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001179446.1 |
|---|
| Aminoacid Length | 548 |
|---|
| Molecular Weight | 57765 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | AJUBA |
|---|
| Gene ID | 519937 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | nucleocytoplasmic Shuttling.Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1-induced NF-kappaB activation.Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. |
|---|
| Biochemical Properties | three tandemly arranged LIM domains in the C-terminal region.The LIM domain defines a unique double zinc finger structure found in a class of proteins involved in cell identity, differentiation, and growth control . The LIM motif,
CX2CX16–23HX2CX2CX2C-X16–21CX2C(D,H).Amino-terminal pre-LIM domain is abundant in glycine and
proline residues.There are two potential SH3 recognition motifs within the pre-LIM domain.pre-LIM domain of Ajuba interacts with the SH3 domains of
Grb2. |
|---|
| PTMs | Phosphorylation on Ser |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BKA3|AJUBA_BOVIN LIM domain-containing protein ajuba OS=Bos taurus OX=9913 GN=AJUBA PE=3 SV=1
MERLGEKASRLLEKLRLSDSGSAKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPR
GAAGGPGDEPLEPAREQGPLDAERNPRGS*89FEVPRYEGSFPGGPPPSRALPLPQSLPPDFR
LETTAPALS*129PRSSFASSSASDAS*143KPSSPRGSLLLDGAGAGGAGGSRPCSNRTSGISMGYD
QRHGS*185PLPAGPCLFGPPLAGVPAGYSSGGVPSAYPELHAALDRLCAHRPAGFGCQESRHS
YPPALGSPGALAGAGVGATGPLERRGAQPGRHS*273VTGYGDCAAGARYQDELTALLRLTVGT
GGREAGVRGESAGIEASGLEEPPGAFVPEAARARIREPESREDYFGTCIKCNKGIYGQSN
ACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLI
LEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKSYAPKCAACGQPI
LPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLSA
RQPPANYI
|
|---|
| Predicted Disorder Regions | 15-118, 128-163, 183-211, 224-277 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Bibliography | Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89. doi: 10.1128/MCB.19.6.4379. PMID: 10330178; PMCID: PMC104397. |
|---|
