Primary Information |
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| BoMiProt ID | Bomi6813 |
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| Protein Name | LIM domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | G5E5X0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001180092.1 |
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| Aminoacid Length | 674 |
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| Molecular Weight | 71885 |
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| FASTA Sequence |
Download |
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| Gene Name | LIMD1 |
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| Gene ID | 617525 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity.Mitotic phosphorylation of LIMD1 is required for its inhibitory activity in cell proliferation and anchorage-independent growth |
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| PTMs | Phosphorylated |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|G5E5X0|LIMD1_BOVIN LIM domain-containing protein 1 OS=Bos taurus OX=9913 GN=LIMD1 PE=3 SV=1
MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEETRRVFATKMAKIHLQQQ
QQQQLLQEETLPRASRGPINGGARLGPPAHREAGGGSKLAADGAAKPPLAASTVAPGTTI
TVAPGQPSYPPQEQRAKLYVRGSRQGS*147QDCGSKESMVNSEMSAFHRPGPCEDPSCLTHGD
YYDNLSLAGPKWADDPGVSPGIRLGVGSGWSGTPGSDPLLSKPSRDPHLYHQQLS*235AGSGR
S*241LQSGQDGGPGGGNSEKPAGVWTTASSQRVS*271PGLPS*276AGPENGALPRSAQPRTPSFSAPLA
LNRPSQGSLPRTNS*314GVGSEVSGTMPKPTVDPQPWFQDGPKSYLSSSAPSSSPASMDHMQA
GALPGLGPKPGSTDPGIGPKLSPNSLVHPVMSTLPELSCKEGASSWASDGSLGPVLPETP
SS*422PRVRLPCQTLIPGPELGPTAAELKLEALTQRLEREMDAHPKADYFGACVKCSKGVFGA
GQACQAMGNLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGH
LIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGL
PILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSCHVKRL
EKGPSPAALRQHHF
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| Predicted Disorder Regions | 5 disordered segments; (71-75), (101-195), (211-314), (330-352), (367-393) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | S272, S277, S421, and S424 are the main phosphorylation sites in LIMD1.phosphorylation of LIMD1 is required for proper mitotic progression. |
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| Bibliography | Zhou J, Zhang L, Zhou W, Chen Y, Cheng Y, Dong J. LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity. FEBS J. 2019 Mar;286(5):963-974. doi: 10.1111/febs.14743. Epub 2019 Jan 16. PMID: 30600590. |
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