Primary Information |
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| BoMiProt ID | Bomi6799 |
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| Protein Name | LIM and cysteine-rich domains protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | Q17QE2 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069690.1 |
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| Aminoacid Length | 363 |
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| Molecular Weight | 40723 |
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| FASTA Sequence |
Download |
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| Gene Name | LMCD1 |
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| Gene ID | 540474 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis |
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| Biochemical Properties | LMCD1 acts as a co-activator for E2F1 in the modulation of thrombin-induced CDC6 expression in promoting HASMC replication. |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q17QE2|LMCD1_BOVIN LIM and cysteine-rich domains protein 1 OS=Bos taurus OX=9913 GN=LMCD1 PE=2 SV=1
MAKVAKDLNPRVQKMS*16LGQQQSARGVPCLRCKGTCSGFEPHSWRKICKSCKCSQEDHCLS
SDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEW
APPGVTQKLGLQYMELIPKEKQPVTGTEGALYRRRQLMHQLPIYDQDPSRCRGLLENELK
VMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETAPPTTNGSIGDPSKEYV
CELCKGVAPADSPVVYSDRAGYSKQWHPACFVCAKCSEPLVDLIYFWKDGAPWCGRHYCE
SLRPRCSGCDEIIFSEDYQRVEDLAWHRKHFVCEGCEQQLGGRAYIVTMGQLLCPTCSKS
KRS
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| Predicted Disorder Regions | 1-27, 52-57, 201-236 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | LMCD1 (LIM and cysteine-rich domains 1) as a gene highly responsive to thrombin in human aortic smooth muscle cells |
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| Bibliography | 1.Janjanam J, Zhang B, Mani AM, Singh NK, Traylor JG Jr, Orr AW, Rao GN. LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis. J Biol Chem. 2018 Mar 2;293(9):3088-3103. doi: 10.1074/jbc.RA117.000866. Epub 2018 Jan 11. PMID: 29326163; PMCID: PMC5836108. 2. |
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