Primary Information |
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| BoMiProt ID | Bomi6770 |
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| Protein Name | Leucine-rich repeat-containing protein 41 |
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| Organism | Bos taurus |
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| Uniprot ID | Q29RR1 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039338.1 |
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| Aminoacid Length | 814 |
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| Molecular Weight | 88677 |
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| FASTA Sequence |
Download |
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| Gene Name | LRRC41 |
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| Gene ID | 337889 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | MUF1 (LRRC41, leucine-rich repeat containing 41) as a potential interaction partner of RhoBTB3 |
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| Biochemical Properties | MUF1 is a largely uncharacterized protein containing a leucine-rich repeat and, interestingly, a BC-box that serves as a linker in multicomponent, cullin 5 (Cul5)-based ubiquitin ligases |
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| PTMs | Phosphorylation at Ser/thr |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q29RR1|LRC41_BOVIN Leucine-rich repeat-containing protein 41 OS=Bos taurus OX=9913 GN=LRRC41 PE=2 SV=1
MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPSAPPALFELCGRAVSAHMGV
LESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAIWRRLWDELMKTRPSSLES
VTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFS*155PLLHSSRHVRQLTICNMLQGATELV
AEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLLHQLIHHGAVSQVSLYSWPVPES
ALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPS*276RDEGSLLLGSRRPRRDAAERCAAA
LMASRRKSEAKQTARAAPATRVTRRS*326T*327QESLTAGGTDSKREPLPPATSHEAPGTKRPPSA
PATTSSASASSSTSS*375SKRAPASSAPQPKPLKRFKRAAGKKGARTRQGCGAESEDLYDFVF
IVAGEKEDGEEMEIGEVACGALDGSDPSCLGLPALEASQRFRSISTLELFTVPLSTEAAL
TLCHLLSSWVSLESLTLSYNGLGSNIFRLLDSLRALSVQAGCRLRALHLSDLFSPLPILE
LTRAIVRALPLLRVLSIRVDHPSQRDNPAVPGNAGPPSNVIGDEEIPENCLEQLEMGFPR
GAQPAPLLCSVLKASGSLQQLSLDSATFASPQDFGLVLQTLKEYNLTLKRLSFHDMNLAD
CQSEVLFLLQNLTLQEITFSFCRLFEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAG
LLALADVFSEDSSSSLCQLDISSNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDA
VTAREAIRRLRATCHVVSDSWDSSQAFADYVSTM
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | LRRK2 is highly phosphorylated with two notable classes of phosphorylation sites, one of autophosphorylation sites clustering in or near LRRK2’s Ras-GTPase-like domain (termed ROC) and another of heterologous phosphorylation sites in the N-terminal ANK-LRR interdomain region.Phosphorylation gives the evidence of a physiological role for an organism.
LRRK2 phosphorylation |
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| Additional Comments | MUF1 is degraded in the proteasome in a Cul5-independent manner by RhoBTB3-Cul3 ubiquitin ligase complex. |
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| Bibliography | 1.Schenková K, Lutz J, Kopp M, Ramos S, Rivero F. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. J Mol Biol. 2012 Oct 5;422(5):659-673. doi: 10.1016/j.jmb.2012.06.016. Epub 2012 Jun 15. PMID: 22709582. 2.Gloeckner, Christian Johannes; Boldt, Karsten; von Zweydorf, Felix; Helm, Sandra; Wiesent, Ludwig; Sarioglu, Hakan; Ueffing, Marius (2010). Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2. Journal of Proteome Research, 9(4), 1738–1745. doi:10.1021/pr9008578. |
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