Search by BoMiProt ID - Bomi6769

Primary Information

BoMiProt ID Bomi6769
Protein Name Leucine-rich repeat-containing protein 14
Organism Bos taurus
Uniprot IDA5PJJ5
Milk FractionWhey
Ref Sequence ID NP_001095849.1
Aminoacid Length 493
Molecular Weight 54918
FASTA Sequence Download
Gene Name LRRC14
Gene ID 539952
Protein Existence Status reviewed

Secondary Information

Protein Function Negatively regulates TLR-mediated NF-kappa-B signaling
Biochemical Properties The LRR sequences following NBDs have two exon arrangements, a singlet (74 nt) containing one motif iteration or a duplex (180 nt) containing two
PTMs Phoshorylation and Ubiquitylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments C-terminal of leucine-rich repeats (LRR) similar in structure to plant disease resistance proteins have been suggested as critical in innate immunity
Bibliography Harton, J. A.; Linhoff, M. W.; Zhang, J.; Ting, J. P.- Y. (2002). Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains. The Journal of Immunology, 169(8), 4088–4093. doi:10.4049/jimmunol.169.8.4088