Primary Information |
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BoMiProt ID | Bomi6769 |
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Protein Name | Leucine-rich repeat-containing protein 14 |
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Organism | Bos taurus |
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Uniprot ID | A5PJJ5 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001095849.1 |
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Aminoacid Length | 493 |
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Molecular Weight | 54918 |
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FASTA Sequence |
Download |
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Gene Name | LRRC14 |
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Gene ID | 539952 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Negatively regulates TLR-mediated NF-kappa-B signaling |
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Biochemical Properties | The LRR sequences following NBDs have two exon arrangements, a singlet (74 nt) containing one motif iteration or a duplex (180 nt) containing two |
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PTMs | Phoshorylation and Ubiquitylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Additional Comments | C-terminal of leucine-rich repeats (LRR) similar in structure to plant disease resistance proteins have been suggested as critical in innate immunity |
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Bibliography | Harton, J. A.; Linhoff, M. W.; Zhang, J.; Ting, J. P.- Y. (2002). Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains. The Journal of Immunology, 169(8), 4088–4093. doi:10.4049/jimmunol.169.8.4088 |