Primary Information |
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| BoMiProt ID | Bomi6769 |
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| Protein Name | Leucine-rich repeat-containing protein 14 |
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| Organism | Bos taurus |
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| Uniprot ID | A5PJJ5 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095849.1 |
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| Aminoacid Length | 493 |
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| Molecular Weight | 54918 |
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| FASTA Sequence |
Download |
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| Gene Name | LRRC14 |
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| Gene ID | 539952 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Negatively regulates TLR-mediated NF-kappa-B signaling |
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| Biochemical Properties | The LRR sequences following NBDs have two exon arrangements, a singlet (74 nt) containing one motif iteration or a duplex (180 nt) containing two |
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| PTMs | Phoshorylation and Ubiquitylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | C-terminal of leucine-rich repeats (LRR) similar in structure to plant disease resistance proteins have been suggested as critical in innate immunity |
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| Bibliography | Harton, J. A.; Linhoff, M. W.; Zhang, J.; Ting, J. P.- Y. (2002). Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains. The Journal of Immunology, 169(8), 4088–4093. doi:10.4049/jimmunol.169.8.4088 |
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