Primary Information |
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| BoMiProt ID | Bomi6768 |
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| Protein Name | Leucine-rich repeat-containing G-protein coupled receptor 5 |
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| Organism | Bos taurus |
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| Uniprot ID | F1MT22 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 907 |
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| Molecular Weight | 99415 |
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| FASTA Sequence |
Download |
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| Gene Name | LGR5 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | member of the G protein-coupled receptors.The ligand for LGR5 is R-spondin, and following ligand-receptor binding, it forms a protein complex with frizzled lipoprotein receptor-related proteins 5 and 6. Subsequently, this complex positively regulates the Wnt signaling pathway . |
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| Biochemical Properties | seven transmembrane domains,contains <18 leucine-rich repeats, each composed of 24 amino acids.The ligand for LGR5 is R-spondin. |
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| PTMs | disulfide bond formation,glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|F1MT22|LGR5_BOVIN Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Bos taurus OX=9913 GN=LGR5 PE=3 SV=2
MDTSSVGVLLSLPVLLQLAAGGGSPRPGTLLRGCPAHCQCEPDGRMLLRVDCSDLGLSEL
PSN*63LSVFTSYLDLSMNN*77ISQLPPSPLHSLRFLEELRLAGNALTYIPKGAFAGLYSLKVLM
LQNNHLRQVPTEALQNLRSLQSLRLDANRISSVPPSCFSGLHSLRHLWLDDNALTEIPVQ
AFRSLSALQAMTLALNKIHHIPDYAFGN*208LSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD
LNYNNLDEFPTAVRTLSNLKELGFHSNNIKSIPEKAFVGNPSLITIHFYDNPIQLVGRSA
FQHLPELRTLTLNGASQITEFPDLTGTASLESLTLTGAQISSLPQTVCDQLPNLQVLDLS
YNLLEDLPSFSVCQKLQKIDLRHNEIYEIQADTFQQLFSLRSLNLAWNKIAIIDPNAFST
LPSLRKLDLSSNRLSSIPVTGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC
AFGVCENVYKISNPWSKGDN*500STAEDLHKKDAGVFQVQDERDLEDFLLDFEEDLRALHPVR
CSPSPGPFKLCEYLFGSWLIRIGVWTIAVLALTCNALVTSTVFRAAVYISSIKLLIGLIA
AVNMLMGVSSAVLAGVDAFTFGSFAQHGAWWEQAVGCQVVGFLSIFASESSVFLLTLAAL
ERGWSVKCSAKFETQTPFPSLRATLALCALLAGTVAAVPLLGGSEYSASPLCLPLPFGEP
RATGYMVALVLLNSLCFLVMTVAYTRLYCHLEKGDLESMWDCSMVKHVALLLFTNCILHC
PVAFLSFSSLLN*792LTFISPEVIKFILLVIVPLPACLNPLLYILFNPHFKEDLGSLGKQTHF
WTRSKHTSLMSINSDDVEKQSCDSTQALVTFTSASIAYDLPSSSGSPPAYPMTESCHLSS
VAFVPCL
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | 7TMHs; (565-587), (594-616), (638-660), (681-703), (722-744),(769-791), (800-822) |
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| Significance of PTMs | Under normal conditions, LGR5 is glycosylated and folded in the ER after translation and is trafficked to the plasma membrane. |
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| Additional Comments | Lgr5 expression was predominantly restricted to the pyloric glands contributing to epithelial self-renewal, and could serve as a unique marker of stem cells in the stomach. |
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| Bibliography | 1.Xi HQ, Cai AZ, Wu XS, Cui JX, Shen WS, Bian SB, Wang N, Li JY, Lu CR, Song Z, Wei B, Chen L. Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis, and could be a potential therapeutic target in human gastric cancer. Br J Cancer. 2014 Apr 15;110(8):2011-20. doi: 10.1038/bjc.2014.112. Epub 2014 Mar 4. PMID: 24594994; PMCID: PMC3992491. 2.Huang T, Qiu X, Xiao J, Wang Q, Wang Y, Zhang Y, Bai D. The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis. Clin Res Hepatol Gastroenterol. 2016 Apr;40(2):246-53. doi: 10.1016/j.clinre.2015.07.009. Epub 2015 Sep 19. PMID: 26387842. |
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