Primary Information |
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| BoMiProt ID | Bomi6708 |
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| Protein Name | Large subunit GTPase 1 homolog |
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| Organism | Bos taurus |
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| Uniprot ID | Q2YDM7 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001039375.1 |
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| Aminoacid Length | 652 |
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| Molecular Weight | 74249 |
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| FASTA Sequence |
Download |
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| Gene Name | LSG1 |
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| Gene ID | 505082 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Role in ribosome biogenesis.required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. |
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| Biochemical Properties | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis.Activation of Lsg1 GTPase requires both Nmd3 and 60S subunits. |
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| PTMs | phosphorylation on See |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2YDM7|LSG1_BOVIN Large subunit GTPase 1 homolog OS=Bos taurus OX=9913 GN=LSG1 PE=2 SV=1
MGRRRAPEGGTLGRALIRQQVQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLD
DFLATAELAGTEFVAEKLNIKFVPPEARTGLLS*93FEENQRIKKLHEENKQFLCIPRRPKWD
QKTSPEELKQAEKDNFLEWRRQLVWLEEEQNLILTPFERNLDFWRQLWRVIERSDIVVQI
VDARNPLLFRCEDLECYVKTIDDNKENVILINKADLLTAEQRSAWAEFFKKENVKVIFWS
ALAEAIKLMGNS*252KGDVNGDTGEAITAEFENSSCDEAEILHKETEHLSLGEAASSEEDESE
YEDCQEEEEDWQTCLEDSSSSDEEACGQDCKEGHTVDSEAQGRNTPQKRQIHNFSHLVSK
QELLEVFKQLHSGKKVKDGQLTVGLVGYPNVGKSSTINTILGNKKVSVSATPGHTKHFQT
LYVEPGLCLCDCPGLVMPSFVSTKAEMICSGILPIDQMRDHVPPVSLVCQNIPRHVLEAT
YGIDIIKPREDEDPRRPPTSEELLTAYGCMRGFMTAHGQPDQPRSARYILKDYVNGKLLY
CHPPPGRDPVTFQYQHQRLLEKKVNGGEIKLQVVRNKKVYQIENVVDKAFFHQENVRALT
KGVQAVMGYKPGSGLVTAAAVSSERGAGKPWKKHGNRNKKEKSRRLYKHLDM
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| Predicted Disorder Regions | 270-346, 492-499, 623-652 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Malyutin AG, Musalgaonkar S, Patchett S, Frank J, Johnson AW. Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. EMBO J. 2017 Apr 3;36(7):854-868. doi: 10.15252/embj.201696012. Epub 2017 Feb 8. PMID: 28179369; PMCID: PMC5376978. |
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