Primary Information |
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| BoMiProt ID | Bomi6619 |
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| Protein Name | KICSTOR complex protein ITFG2/Adrenal medulla 50 kDa protein/Integrin-alpha FG-GAP repeat-containing protein 2 |
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| Organism | Bos taurus |
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| Uniprot ID | Q27969 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776987.1 |
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| Aminoacid Length | 532 |
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| Molecular Weight | 58160 |
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| FASTA Sequence |
Download |
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| Gene Name | ITFG2/ADP50 |
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| Gene ID | 282275 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 |
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| Biochemical Properties | strong interaction between KICSTOR and GATOR1, which is an inhibitor of the Rag GTPases indicates that KICSTOR might be required for the control of the mTORC1 pathway by amino acids |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q27969|ITFG2_BOVIN KICSTOR complex protein ITFG2 OS=Bos taurus OX=9913 GN=ITFG2 PE=2 SV=1
MRSVSYVQRVALEFSGSLFPHAICLGDVDNDTLNELVVGDTSGKLSVYKNDDSRPWLTCS
CQGMLTCVGVGDVCNKGKNLVVAVSAEGWFHLCDLTPAKSLDGS*104GHHETLGGEEQRPVFK
QHIPANTKVMLISDIDGDGRCELVVGYTDRVVRAFRWEDLGEGAEHPMGQLVLLKKWMLE
GQVDSLSVTPGPLGVPELMVSQPGCAYAILLCTWNKDPGATPTSEGPMEGHSGAPGCPGR
CVAPDLWPHPQQERLHSPHRQHQASHSPDSSASGLFALCTLDGTLKLMEEADRLLWSVQV
DHQLFALEKLDVTGNGHEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGLYACKDS
RNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKVLEAQPSSGSCWESWAWILMSCPPPAP
CFTKPSTIQTSLHSAPPRAPRTPPSWTGFLAEQGAFCTSPPPPPPQLSGIWKTGSAHYWG
RMAAPLGCGDCRPPGRLGEGRDKLPLCPFPCVPHLSRQQALPLPRAPYSCCL
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| Predicted Disorder Regions | 218-270, 434-445, 459-461 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and may mediate the direct interaction with the GATOR complex via GATOR1 |
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| Bibliography | 1. Wolfson, Rachel L.; Chantranupong, Lynne; Wyant, Gregory A.; Gu, Xin; Orozco, Jose M.; Shen, Kuang; Condon, Kendall J.; Petri, Sabrina; Kedir, Jibril; Scaria, Sonia M.; Abu-Remaileh, Monther; Frankel, Wayne N.; Sabatini, David M. (2017). KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature, 543(7645), 438–442.doi:10.1038/nature21423. 2. |
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