Primary Information
BoMiProt ID	Bomi6600
Protein Name	Kelch-like protein 3
Organism	Bos taurus
Uniprot ID	F1MBP6
Milk Fraction	Whey
Ref Sequence ID	XP_002689253.2
Aminoacid Length	587
Molecular Weight	64978
FASTA Sequence	Download
Gene Name	KLHL3
Gene ID	533364
Protein Existence Status	reviewed
Secondary Information
Protein Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron.
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|F1MBP6|KLHL3_BOVIN Kelch-like protein 3 OS=Bos taurus OX=9913 GN=KLHL3 PE=3 SV=3 MDGESIKPSS*10QPLIQTGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR LPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRT*295PVSLP KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR VRTVDVYDGVKDQWT*375S*376IASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE WFFVAPMNTRRSS*433VGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWTYVADMSTRR SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLY VVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKPL
Predicted Disorder Regions	(1-27)
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	Phosphorylation at Ser-433 by PKA decreases the interaction with WNK4, Leading to inhibit WNK4 degradation by the BCR(KLHL3) complex. Phosphorylation at Ser-433 is increased by insulin.
Bibliography	Zimin, A. V., Delcher, A. L., Florea, L., Kelley, D. R., Schatz, M. C., Puiu, D., Hanrahan, F., Pertea, G., Van Tassell, C. P., Sonstegard, T. S., Marçais, G., Roberts, M., Subramanian, P., Yorke, J. A., & Salzberg, S. L. (2009). A whole-genome assembly of the domestic cow, Bos taurus. Genome biology, 10(4), R42. https://doi.org/10.1186/gb-2009-10-4-r42