Search by BoMiProt ID - Bomi6587

Primary Information

BoMiProt ID Bomi6587
Protein Name Kelch domain-containing protein 8B
Organism Bos taurus
Uniprot IDQ5E9V5
Milk FractionWhey
Ref Sequence ID NP_001030447.2
Aminoacid Length 354
Molecular Weight 37540
FASTA Sequence Download
Gene Name KLHDC8B
Gene ID 527321
Protein Existence Status reviewed

Secondary Information

Protein Function Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis.Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells .
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Krem MM, Luo P, Ing BI, Horwitz MS. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. J Biol Chem. 2012 Nov 9;287(46):39083-93. doi: 10.1074/jbc.M112.390088. Epub 2012 Sep 17. PMID: 22988245; PMCID: PMC3493949.