Primary Information
BoMiProt ID	Bomi6587
Protein Name	Kelch domain-containing protein 8B
Organism	Bos taurus
Uniprot ID	Q5E9V5
Milk Fraction	Whey
Ref Sequence ID	NP_001030447.2
Aminoacid Length	354
Molecular Weight	37540
FASTA Sequence	Download
Gene Name	KLHDC8B
Gene ID	527321
Protein Existence Status	reviewed
Secondary Information
Protein Function	Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis.Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells .
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	no TM helices
Bibliography	Krem MM, Luo P, Ing BI, Horwitz MS. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. J Biol Chem. 2012 Nov 9;287(46):39083-93. doi: 10.1074/jbc.M112.390088. Epub 2012 Sep 17. PMID: 22988245; PMCID: PMC3493949.