Primary Information
BoMiProt ID	Bomi6586
Protein Name	Kelch domain-containing protein 2
Organism	Bos taurus
Uniprot ID	Q5E9A7
Milk Fraction	Whey
Ref Sequence ID	NP_001014948.1
Aminoacid Length	406
Molecular Weight	46125
FASTA Sequence	Download
Gene Name	KLHDC2
Gene ID	535436
Protein Existence Status	reviewed
Secondary Information
Protein Function	mKlhdc2 plays an essential role in muscle cell migration and differentiation, potentially by acting on the cytoskeleton remodeling of myoblasts
Biochemical Properties	It belongs to the family of Kelch domain containing proteins, which are known to be involved in such diverse biological functions as transcriptional activation or repression, actin remodeling or stabilization and cell adhesion.In the case of mKlhdc2, the propeller consists of six β-sheets and essentially covers the whole protein, with no other motives detectable by database searches. mKlhdc2 shows the highest homology to its human orthologue hKlhdc2 (also named HCLP1,and host cell factor 1 (HCF1). mKlhdc2 and hKlhdc2 are 79% identical on the nucleotide level and 96% identical on the protein level.
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Additional Comments	Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.
Bibliography	1.Neuhaus P, Jaschinsky B, Schneider S, Neuhaus H, Wolter A, Ebelt H, Braun T. Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts. Exp Cell Res. 2006 Oct 1;312(16):3049-59. doi: 10.1016/j.yexcr.2006.06.006. Epub 2006 Jun 15. PMID: 16860314. 2.] H.J. Zhou, C.M. Wong, J.H. Chen, B.Q. Qiang, J.G. Yuan, D. Jin, Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein, J. Biol. Chem. 276 (2001) 28933–28938. 3. J. Adams, R. Kelso, L. Cooley, The kelch repeat superfamily of proteins: propellers of cell function, Trends Cell Biol. 10 (2000) 17–24.