Search by BoMiProt ID - Bomi6585

Primary Information

BoMiProt ID Bomi6585
Protein Name Kelch domain-containing protein 10
Organism Bos taurus
Uniprot IDQ0IIC2
Milk FractionWhey
Ref Sequence ID NP_001068695.1
Aminoacid Length 442
Molecular Weight 49111
FASTA Sequence Download
Gene Name KLHDC10
Gene ID 505844
Protein Existence Status reviewed

Secondary Information

Protein Function This protein participates in the oxidative stress-induced cell death through MAP3K5 activation. It acts as a regulator of necroptosis. It is a substrate-recognition component of a CRL2 E3 ubi-protein ligase complex of the DesCEND pathway and is involved in pathway protein ubiquitination.
Biochemical Properties composed of the kelch repeat domain that consists of six repeated kelch motifs.KLHDC10 Interacts with PP5 through Phosphatase Domain of PP5.KLHDC10 Is Required for H2O2-Induced sustained activation of ASK1 and cell death.
PTMs Methylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions (1-40), (54-58)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K., & Ichijo, H. (2012). The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Molecular cell, 48(5), 692–704.