Search by BoMiProt ID - Bomi6523

Primary Information

BoMiProt ID Bomi6523
Protein Name Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial/Isocitric dehydrogenase subunit gamma/NAD(+)-specific ICDH subunit gamma
Organism Bos taurus
Uniprot IDQ58CP0
Milk FractionWhey
Ref Sequence ID NP_001069781.1
Aminoacid Length 392
Molecular Weight 42863
FASTA Sequence Download
Gene Name IDH3G
Gene ID 614145
Protein Existence Status reviewed

Secondary Information

Protein Function Regulatory subunit of NAD-dependent isocitrate dehydrogenase which catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle.
Biochemical Properties N-terminal of the γ subunit plays a critical role in the formation of the heterooctamer to ensure the optimal activity of the enzyme.Mn2+ or Mg2+ as cofactor
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Sun P, Liu Y, Ma T, Ding J. Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase. Cell Discov. 2020 Dec 22;6(1):94. doi: 10.1038/s41421-020-00220-7. PMID: 33349631; PMCID: PMC7752914.