Primary Information |
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BoMiProt ID | Bomi6523 |
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Protein Name | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial/Isocitric dehydrogenase subunit gamma/NAD(+)-specific ICDH subunit gamma |
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Organism | Bos taurus |
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Uniprot ID | Q58CP0 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001069781.1 |
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Aminoacid Length | 392 |
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Molecular Weight | 42863 |
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FASTA Sequence |
Download |
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Gene Name | IDH3G |
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Gene ID | 614145 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | Regulatory subunit of NAD-dependent isocitrate dehydrogenase which catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. |
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Biochemical Properties | N-terminal of the γ subunit plays a critical role in the formation of the heterooctamer to ensure the optimal activity of the enzyme.Mn2+ or Mg2+ as cofactor |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Sun P, Liu Y, Ma T, Ding J. Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase. Cell Discov. 2020 Dec 22;6(1):94. doi: 10.1038/s41421-020-00220-7. PMID: 33349631; PMCID: PMC7752914. |