Primary Information |
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| BoMiProt ID | Bomi6523 |
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| Protein Name | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial/Isocitric dehydrogenase subunit gamma/NAD(+)-specific ICDH subunit gamma |
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| Organism | Bos taurus |
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| Uniprot ID | Q58CP0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001069781.1 |
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| Aminoacid Length | 392 |
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| Molecular Weight | 42863 |
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| FASTA Sequence |
Download |
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| Gene Name | IDH3G |
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| Gene ID | 614145 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Regulatory subunit of NAD-dependent isocitrate dehydrogenase which catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. |
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| Biochemical Properties | N-terminal of the γ subunit plays a critical role in the formation of the heterooctamer to ensure the optimal activity of the enzyme.Mn2+ or Mg2+ as cofactor |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Sun P, Liu Y, Ma T, Ding J. Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase. Cell Discov. 2020 Dec 22;6(1):94. doi: 10.1038/s41421-020-00220-7. PMID: 33349631; PMCID: PMC7752914. |
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