Search by BoMiProt ID - Bomi6505

Primary Information

BoMiProt ID Bomi6505
Protein Name Ion channel TACAN/Transmembrane protein 120A
Organism Bos taurus
Uniprot IDQ05B45
Milk FractionWhey
Ref Sequence ID NP_001073068.1
Aminoacid Length 343
Molecular Weight 40730
FASTA Sequence Download
Gene Name TMEM120A
Gene ID 520173
Protein Existence Status reviewed

Secondary Information

Protein Function main function is mechanotransduction, the conversion of mechanical stimuli into electrical signals.responsiveness to touch and pain sensing, hearing, and proprioception.
Significance in milk TACAN Is an Ion Channel Involved in Sensing Mechanical Pain
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-17, 55-57, 338-343
DisProt Annotation
TM Helix Prediction 4TMHs; (138-156), (192-210), (272-294), (307-329)
Additional Comments knockout of TACAN decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but not to thermal or touch stimuli. 
Bibliography Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, Haglund L, Ouellet JA, Stone LS, Samson J, Smith MJ, Ask K, Ribeiro-da-Silva A, Blunck R, Poole K, Bourinet E, Sharif-Naeini R. TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. 2020 Mar 5;180(5):956-967.e17. doi: 10.1016/j.cell.2020.01.033. Epub 2020 Feb 20. PMID: 32084332.