Search by BoMiProt ID - Bomi6490


Primary Information

BoMiProt ID Bomi6490
Protein Name Interleukin-12 subunit alpha
Organism Bos taurus
Uniprot IDP54349
Milk FractionWhey,Casein
Ref Sequence ID NP_776780.1
Aminoacid Length 155
Molecular Weight 15720
FASTA Sequence Download
Gene Name IL12A
Gene ID 281856
Protein Existence Status reviewed

Secondary Information

Protein Function Induces interferon in natural killer cells and T cells and, as such, may play a major role in cell-mediated immunity.IL-12 is a natural killer cell stimulatory factor.An important factor for the differentiation of naive T cells into T-helper type 1 CD4+ lymphocytes secreting interferon-gamma ,T-cell-dependent immune and inflammatory responses.
Biochemical Properties IL-12 is a glycosylated, 75 kDa heterodimeric cytokine comprised of disulfide-bonded 35 kDa and 40 kDa subunits. When it forms heterodimer with EBI3/IL27B without any disulfide-linked. This heterodimer is known as IL-35.
Significance in milk a cytokine marker in Staphylococcus aureus mastitis of bovine mammary gland
PTMs N linked Glycosylation on Asn
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P54349|IL12A_BOVIN Interleukin-12 subunit alpha OS=Bos taurus OX=9913 GN=IL12A PE=2 SV=1 MCPLRSLLLISTLVLLHHLPHLSLGRSLPTTTASPGRSCLDYSQNLLRAVSNTLQKARQT LEFYSCTSEEIDHEDITKDKTSTVEACLPLELATN*95ESCLASRETSFITNGHCLASGKTSF MTTLCLRSIYEDLKMYHVEFQAMNAKLLMDPKRQIFLDQNMLAAIAELMQALNFDSETVP QKPSLKELDFYKTKVKLCILLHAFRIRAVTIDRMMSYLSSS
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Zarlenga DS, Canals A, Aschenbrenner RA, Gasbarre LC. Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12. Biochim Biophys Acta. 1995 Apr 24;1270(2-3):215-7. doi: 10.1016/0925-4439(95)00042-3. PMID: 7727547.