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Primary Information | |
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| BoMiProt ID | Bomi6460 |
| Protein Name | Interferon gamma/BoIFNG/IFN-gamma |
| Organism | Bos taurus |
| Uniprot ID | P07353 |
| Milk Fraction | Whey |
| Ref Sequence ID | NP_776511.1 |
| Aminoacid Length | 166 |
| Molecular Weight | 19393 |
| FASTA Sequence | Download |
| Gene Name | IFNG |
| Gene ID | 281237 |
| Protein Existence Status | reviewed |
Secondary Information | |
| Protein Function | secreted by CD4+ T helper cell type 1 (Th1) lymphocytes, CD8+ cytotoxic lymphocytes,NK cells, B cells, NKT cells, and professional antigen-presenting cells (APCs).up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. |
| Significance in milk | cow milk allergy |
| PTMs | Glycosylation |
| Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | >sp|P07353|IFNG_BOVIN Interferon gamma OS=Bos taurus OX=9913 GN=IFNG PE=1 SV=1 MKYTSYFLALLLCGLLGFSGSYGQGQFFREIENLKEYFN*39ASSPDVAKGGPLFSEILKNWK DESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLN*106GSSEKLEDFKKLIQ IPVDDLQIQRKAINELIKVMNDLSPKSNLRKRKRSQNLFRGRRASM |
| SCOP | Class : All alpha proteins Fold : 4-helical cytokines Superfamily : 4-helical cytokines Family : Interferons/interleukin-10 (IL-10) Domain Name : 1D9C A:1-121 |
| CATH | Matched CATH superfamily 1.20.1250.10 |
| Predicted Disorder Regions | 141-166 |
| DisProt Annotation | |
| TM Helix Prediction | 1TMH; (7-25) |
| PDB ID | 1D9C,1D9G,1RFB, |
| Additional Comments | FN-γ primarily signals through the Jak-Stat pathway.binds to IFN-γ receptor |
| Bibliography | Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 2004 Feb;75(2):163-89. doi: 10.1189/jlb.0603252. Epub 2003 Oct 2. PMID: 14525967. |