Primary Information |
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| BoMiProt ID | Bomi6455 |
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| Protein Name | Interferon alpha-inducible protein 6 |
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| Organism | Bos taurus |
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| Uniprot ID | Q6IED8 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_001069056.1 |
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| Aminoacid Length | 134 |
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| Molecular Weight | 13992 |
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| FASTA Sequence |
Download |
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| Gene Name | IFI6 |
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| Gene ID | 512913 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Increased expression of IFI6 has been associated with the anti-apoptotic activity of IFN-α2b.FI6 is a mitochondria-targeted protein, inhibits the release of cytochrome c from mitochondria and delays the apoptotic process initiated and transduced by the TNF-related apoptosis-inducing ligand/caspase 8 pathway. IFI6, via E2F2 regulates DNA replication and melanoma development and growth. impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. |
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| PTMs | Glycosylated. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 3 disordered segments; (24-38), (83-86), (118-134) |
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| DisProt Annotation | |
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| TM Helix Prediction | 3TMHs ; (41-63),(70-92) and (101-119) |
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| Bibliography | Meyer K, Kwon YC, Liu S, Hagedorn CH, Ray RB, Ray R. Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. Sci Rep. 2015 Mar 11;5:9012. doi: 10.1038/srep09012. PMID: 25757571; PMCID: PMC4355636. |
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