Search by BoMiProt ID - Bomi6455


Primary Information

BoMiProt ID Bomi6455
Protein Name Interferon alpha-inducible protein 6
Organism Bos taurus
Uniprot IDQ6IED8
Milk FractionWhey,MFGM
Ref Sequence ID NP_001069056.1
Aminoacid Length 134
Molecular Weight 13992
FASTA Sequence Download
Gene Name IFI6
Gene ID 512913
Protein Existence Status reviewed

Secondary Information

Protein Function Increased expression of IFI6 has been associated with the anti-apoptotic activity of IFN-α2b.FI6 is a mitochondria-targeted protein, inhibits the release of cytochrome c from mitochondria and delays the apoptotic process initiated and transduced by the TNF-related apoptosis-inducing ligand/caspase 8 pathway. IFI6, via E2F2 regulates DNA replication and melanoma development and growth. impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.
PTMs Glycosylated.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 3 disordered segments; (24-38), (83-86), (118-134)
DisProt Annotation
TM Helix Prediction 3TMHs ; (41-63),(70-92) and (101-119)
Bibliography Meyer K, Kwon YC, Liu S, Hagedorn CH, Ray RB, Ray R. Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. Sci Rep. 2015 Mar 11;5:9012. doi: 10.1038/srep09012. PMID: 25757571; PMCID: PMC4355636.