Primary Information
BoMiProt ID	Bomi6451
Protein Name	Inter-alpha-trypsin inhibitor heavy chain H5/ITI heavy chain H5/ITI-HC5/Inter-alpha-inhibitor heavy chain 5
Organism	Bos taurus
Uniprot ID	A2VE29
Milk Fraction	Whey
Ref Sequence ID	NP_001095986.1
Aminoacid Length	940
Molecular Weight	104356
FASTA Sequence	Download
Gene Name	ITIH5
Gene ID	534787
Protein Existence Status	reviewed
Secondary Information
Protein Function	Interacts with HA(Hyaluronan),participate in ECM stabilization and epidermal differentiation,also modulating epidermal differentiation.
PTMs	Glycosylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|A2VE29|ITIH5_BOVIN Inter-alpha-trypsin inhibitor heavy chain H5 OS=Bos taurus OX=9913 GN=ITIH5 PE=2 SV=1 MLPLLGLCFALPLCAGLLEEARSWEDTSDQVGLRIPRQVRLLQRLKTKPLMTEFSVKSTI ISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITN*97FTALIGDKVYQGEITEREKRNGD KVKEKRN*127KTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQ LVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQN*231ETFAKVVFK PSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVL DSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKV YIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTFKIL N*421NTREATRGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRT PLLSDIRVDYPPSLVERATRTLFPNYFN*508GSEIVIAGKLVDRAMDRLHVEVTASNSKKFVV LKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERER LRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQ PGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSN*694LTVCFNIDGEPGHILRLVSDHADSGV TVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCN*778QS AVVGRRGLEVSVSAN*795ASVTISIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNC HGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQV DCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL
Predicted Disorder Regions	NA
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	1.Huth S, Huth L, Marquardt Y, Fietkau K, Dahl E, Esser PR, Martin SF, Heise R, Merk HF, Baron JM. Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin. Skin Pharmacol Physiol. 2020;33(4):198-206. doi: 10.1159/000509371. Epub 2020 Aug 14. PMID: 32799206.