Primary Information
BoMiProt ID	Bomi6427
Protein Name	Integrator complex subunit 7/Int7
Organism	Bos taurus
Uniprot ID	Q1RMS6
Milk Fraction	whey
Ref Sequence ID	NP_001069512.1
Aminoacid Length	962
Molecular Weight	106771
FASTA Sequence	Download
Gene Name	INTS7
Gene ID	534964
Protein Existence Status	Reviewed
Secondary Information
Protein Function	It is a component of the Integrator (INT) complex which is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Biochemical Properties	The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes
PTMs	Phosphorylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	>sp|Q1RMS6|INT7_BOVIN Integrator complex subunit 7 OS=Bos taurus OX=9913 GN=INTS7 PE=2 SV=1 MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPIL INSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKI SEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTAYPSTRMVIVSLHTFTL LAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECAL QTPYDSLKLGMLSVLATLSGTIAVKHYFSIASGNVGSS*338PRSSDLVKLAQECCYHNNRGIA AHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLA KGRPHLSQSVVETLLTQLHSAQDTARILMCHCLAAIAMQLPVLGDGMLGDLVELYKVIGR SATDKQQELLVSLATVIFVASQKALSAEVKAVIKQQLESVSNGWTVYRIARQASRMGNHD MARELYQTLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKG IASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGND LQRCGRISNQMKLSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEAL ILDPESASFQEYGSTGAAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNA IISLLKVPLSFQRYFFQKLQSTSIKLALS*809PSPRNPAEPIAVQNNQQLALKVEGVVQHGSK PGLFRRIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILG THNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYT RF
Predicted Disorder Regions	936-962
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Li, X., Yao, Y., Qian, J., Jin, G., Zeng, G., & Zhao, H. (2021). Overexpression and diagnostic significance of INTS7 in lung adenocarcinoma and its effects on tumor microenvironment. International immunopharmacology, 101(Pt B), 108346. https://doi.org/10.1016/j.intimp.2021.108346