Search by BoMiProt ID - Bomi6398

Primary Information

BoMiProt ID Bomi6398
Protein Name INO80 complex subunit E/Coiled-coil domain-containing protein 95
Organism Bos taurus
Uniprot IDQ29RS4
Milk FractionWhey
Ref Sequence ID NP_001040009.1
Aminoacid Length 244
Molecular Weight 26384
FASTA Sequence Download
Gene Name INO80E/CCDC95
Gene ID 614852
Protein Existence Status reviewed

Secondary Information

Protein Function Slide nucleosomes away from DNA ends.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Biochemical Properties INO80E binds to SUMO1 and SUMO2 through a C-terminal SIM domain during post translational modification.contain a C-terminal domain (CTD) that negatively regulates ATPase activity of the hINO80 complex .Ino80 subunit lacks AutoN and NegC motifs
PTMs isopeptide bond formation,Ubl conjugation,SUMOylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Predicted Disorder Regions 1-21, 33-244
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs SUMOylation is regulating the INO80 chromatin remodeling complex.SUMOylation of the INO80 complex subunit TFPT primes the protein for interaction with INO80E, via its SUMO interaction motif.
Bibliography 1.Cox E, Hwang W, Uzoma I, Hu J, Guzzo CM, Jeong J, Matunis MJ, Qian J, Zhu H, Blackshaw S. Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics. 2017 May;16(5):812-823. doi: 10.1074/mcp.M116.063719. Epub 2017 Mar 2. PMID: 28254775; PMCID: PMC5417823.