Primary Information |
|---|
| BoMiProt ID | Bomi6398 |
|---|
| Protein Name | INO80 complex subunit E/Coiled-coil domain-containing protein 95 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot ID | Q29RS4 |
|---|
| Milk Fraction | Whey |
|---|
| Ref Sequence ID | NP_001040009.1 |
|---|
| Aminoacid Length | 244 |
|---|
| Molecular Weight | 26384 |
|---|
| FASTA Sequence |
Download |
|---|
| Gene Name | INO80E/CCDC95 |
|---|
| Gene ID | 614852 |
|---|
| Protein Existence Status | reviewed |
|---|
Secondary Information |
|---|
| Protein Function | Slide nucleosomes away from DNA ends.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. |
|---|
| Biochemical Properties | INO80E binds to SUMO1 and SUMO2 through a C-terminal SIM domain during post translational modification.contain a C-terminal domain (CTD) that negatively regulates ATPase activity of the hINO80 complex .Ino80 subunit lacks AutoN and NegC motifs |
|---|
| PTMs | isopeptide bond formation,Ubl conjugation,SUMOylation |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
|---|
| Predicted Disorder Regions | 1-21, 33-244 |
|---|
| DisProt Annotation | |
|---|
| TM Helix Prediction | No TM helices |
|---|
| Significance of PTMs | SUMOylation is regulating the INO80 chromatin remodeling complex.SUMOylation of the INO80 complex subunit TFPT primes the protein for interaction with INO80E, via its SUMO interaction motif. |
|---|
| Bibliography | 1.Cox E, Hwang W, Uzoma I, Hu J, Guzzo CM, Jeong J, Matunis MJ, Qian J, Zhu H, Blackshaw S. Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics. 2017 May;16(5):812-823. doi: 10.1074/mcp.M116.063719. Epub 2017 Mar 2. PMID: 28254775; PMCID: PMC5417823. |
|---|
