Primary Information |
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| BoMiProt ID | Bomi6394 |
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| Protein Name | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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| Organism | Bos taurus |
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| Uniprot ID | Q95KV0 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_776778.1 |
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| Aminoacid Length | 756 |
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| Molecular Weight | 86647 |
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| FASTA Sequence |
Download |
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| Gene Name | IKBKB |
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| Gene ID | 281854 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Serine kinase that plays an essential role in the NF-kappa-B signaling pathway |
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| PTMs | Hydroxylation, Isopeptide bond formation, Phosphorylation, S-nitrosylation, Ubl conjugation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q95KV0|IKKB_BOVIN Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Bos taurus OX=9913 GN=IKBKB PE=2 SV=1
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGS*177LCT
S*181FVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA
LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN
LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI
ACSKVRGPVS*670GS*672PDS*675MNASRLS*682HPCQLMS*689QPCTAPDS*697LPEAAEKS*705EDLVAEAHTLCTQLENALQDTMKEQDQS*733LRSLDWS*740WLQSEEEEQQSLERAS
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| Predicted Disorder Regions | 576-585, 665-756 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Ubiquitination on 'Ser-163' may modulate phosphorylation on C-terminal serine residues. |
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