Search by BoMiProt ID - Bomi6394


Primary Information

BoMiProt ID Bomi6394
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Organism Bos taurus
Uniprot IDQ95KV0
Milk FractionWhey
Ref Sequence ID NP_776778.1
Aminoacid Length 756
Molecular Weight 86647
FASTA Sequence Download
Gene Name IKBKB
Gene ID 281854
Protein Existence Status reviewed

Secondary Information

Protein Function Serine kinase that plays an essential role in the NF-kappa-B signaling pathway
PTMs Hydroxylation, Isopeptide bond formation, Phosphorylation, S-nitrosylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q95KV0|IKKB_BOVIN Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Bos taurus OX=9913 GN=IKBKB PE=2 SV=1 MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGS*177LCT S*181FVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI ACSKVRGPVS*670GS*672PDS*675MNASRLS*682HPCQLMS*689QPCTAPDS*697LPEAAEKS*705EDLVAEAHTLCTQLENALQDTMKEQDQS*733LRSLDWS*740WLQSEEEEQQSLERAS
Predicted Disorder Regions 576-585, 665-756
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Ubiquitination on 'Ser-163' may modulate phosphorylation on C-terminal serine residues.