Primary Information |
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| BoMiProt ID | Bomi6339 |
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| Protein Name | Hydroxylysine kinase/5-hydroxy-L-lysine kinase/Aminoglycoside phosphotransferase domain-containing protein 1 |
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| Organism | Bos taurus |
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| Uniprot ID | A5PJU6 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001092517.1 |
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| Aminoacid Length | 376 |
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| Molecular Weight | 42077 |
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| FASTA Sequence |
Download |
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| Gene Name | HYKK/AGPHD1 |
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| Gene ID | 530270 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | involved in lysine metabolism.Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine. |
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| Biochemical Properties | this enzyme belong to transferases. catalyze the GTP-dependent phosphorylation of 5-hydroxy-l-lysine.The phosphorylation product made by this enzyme was metabolized by AGXT2L2, which converted it to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. AGXT2L1 catalyzed a similar reaction on phosphoethanolamine, converting it to ammonia, inorganic phosphate, and acetaldehyde. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | (1-16) |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J Biol Chem. 2012 Mar 2;287(10):7246-55. doi: 10.1074/jbc.M111.323485. Epub 2012 Jan 12. PMID: 22241472; PMCID: PMC3293546. |
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