Primary Information |
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BoMiProt ID | Bomi6317 |
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Protein Name | Homeobox protein PKNOX1/PBX/knotted homeobox 1 |
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Organism | Bos taurus |
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Uniprot ID | Q2HJ84 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001039815.1 |
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Aminoacid Length | 436 |
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Molecular Weight | 47204 |
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FASTA Sequence |
Download |
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Gene Name | PKNOX1/PREP1 |
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Gene ID | 533382 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | PKNOX1 exerts tumor suppressive activity.The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression. |
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PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q2HJ84|PKNX1_BOVIN Homeobox protein PKNOX1 OS=Bos taurus OX=9913 GN=PKNOX1 PE=2 SV=1
MMATQTLSIDSYPDGQQMQVVTELKTEQDPNCS*33EPDVEGVS*41PPPVGSQTPMDADKQAIYR
HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK
AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI
TGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVVTPQGQVVTQALSPGTIRIQNSQ
LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN
LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGAAQPAAS
ELTVSEGAVVTITAPVSMNVDSLQSLSSDGATLAVQQVMMAEQSEDDSVDSTGDGGAALA
PGHLGGLVLENSDSLQ |
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Predicted Disorder Regions | 3 disordered segments; (1-55), (79-85), (104-109) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Bisaillon R, Wilhelm BT, Krosl J, Sauvageau G. C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein. Blood. 2011 Oct 27;118(17):4682-9. doi: 10.1182/blood-2011-05-354076. Epub 2011 Sep 7. PMID: 21900201. |